Academic Journal
A novel superfamily of bridge-like lipid transfer proteins
| العنوان: | A novel superfamily of bridge-like lipid transfer proteins |
|---|---|
| المؤلفون: | Neuman, Sarah D, Levine, Tim P, Bashirullah, Arash |
| المصدر: | Trends in Cell Biology , 32 (11) pp. 962-974. (2022) |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2022 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | AlphaFold, Vps13, autophagy, lipid transfer proteins, lipids, membrane contact sites |
| الوصف: | Lipid transfer proteins mediate nonvesicular transport of lipids at membrane contact sites to regulate the lipid composition of organelle membranes. Recently, a new type of bridge-like lipid transfer protein has emerged; these proteins contain a long hydrophobic groove and can mediate bulk transport of lipids between organelles. Here, we review recent insights into the structure of these proteins and identify a repeating modular unit that we propose to name the repeating β-groove (RBG) domain. This new structural understanding conceptually unifies all the RBG domain-containing lipid transfer proteins as members of an RBG protein superfamily. We also examine the biological functions of these lipid transporters in normal physiology and disease and speculate on the evolutionary origins of RBG proteins in bacteria. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| Relation: | https://discovery.ucl.ac.uk/id/eprint/10150146/1/Neuman%20Feb%209%202022%20TCB%20composite.pdf; https://discovery.ucl.ac.uk/id/eprint/10150146/ |
| الاتاحة: | https://discovery.ucl.ac.uk/id/eprint/10150146/1/Neuman%20Feb%209%202022%20TCB%20composite.pdf https://discovery.ucl.ac.uk/id/eprint/10150146/ |
| Rights: | open |
| رقم الانضمام: | edsbas.D1ACE178 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |