Academic Journal
Short-term quality of life after subthalamic stimulation depends on non-motor symptoms in Parkinson's disease
| العنوان: | Short-term quality of life after subthalamic stimulation depends on non-motor symptoms in Parkinson's disease |
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| المؤلفون: | Haidar Salimi Dafsari, Luisa Weiß, Monty Silverdale, Alexandra Rizos, Prashanth Reddy, Keyoumars Ashkan, Julian Evans, Paul Reker, Jan Niklas Petry-Schmelzer, Michael Samuel, Veerle Visser-Vandewalle, Angelo Antonini, Pablo Martinez-Martin, K. Ray-Chaudhuri, Lars Timmermann |
| المصدر: | Brain Stimulation, Vol 11, Iss 4, Pp 867-874 (2018) |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2018 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Deep brain stimulation, Subthalamic nucleus, Non motor symptoms, Parkinson's Disease Questionnaire, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: | Background: Subthalamic nucleus (STN) deep brain stimulation (DBS) improves quality of life (QoL), motor, and non-motor symptoms (NMS) in advanced Parkinson's disease (PD). However, considerable inter-individual variability has been observed for QoL outcome. Hypothesis: We hypothesized that demographic and preoperative NMS characteristics can predict postoperative QoL outcome. Methods: In this ongoing, prospective, multicenter study (Cologne, Manchester, London) including 88 patients, we collected the following scales preoperatively and on follow-up 6 months postoperatively: PDQuestionnaire-8 (PDQ-8), NMSScale (NMSS), NMSQuestionnaire (NMSQ), Scales for Outcomes in PD (SCOPA)-motor examination, -complications, and –activities of daily living, levodopa equivalent daily dose. We dichotomized patients into “QoL responders”/“non-responders” and screened for factors associated with QoL improvement with (1) Spearman-correlations between baseline test scores and QoL improvement, (2) step-wise linear regressions with baseline test scores as independent and QoL improvement as dependent variables, (3) logistic regressions using aforementioned “responders/non-responders” as dependent variable. Results: All outcomes improved significantly on follow-up. However, approximately 44% of patients were categorized as “QoL non-responders”. Spearman-correlations, linear and logistic regression analyses were significant for NMSS and NMSQ but not for SCOPA-motor examination. Post-hoc, we identified specific NMS (flat moods, difficulties experiencing pleasure, pain, bladder voiding) as significant contributors to QoL outcome. Conclusions: Our results provide evidence that QoL improvement after STN-DBS depends on preoperative NMS characteristics. These findings are important in the advising and selection of individuals for DBS therapy. Future studies investigating motor and non-motor PD clusters may enable stratifying QoL outcomes and help predict patients' individual prospects of benefiting from DBS. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1935-861X |
| Relation: | http://www.sciencedirect.com/science/article/pii/S1935861X18300780; https://doaj.org/toc/1935-861X; https://doaj.org/article/5505ef8bcb9849179ebf58b3cb543dd3 |
| DOI: | 10.1016/j.brs.2018.02.015 |
| الاتاحة: | https://doi.org/10.1016/j.brs.2018.02.015 https://doaj.org/article/5505ef8bcb9849179ebf58b3cb543dd3 |
| رقم الانضمام: | edsbas.D1AA2B85 |
| قاعدة البيانات: | BASE |
| تدمد: | 1935861X |
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| DOI: | 10.1016/j.brs.2018.02.015 |