التفاصيل البيبلوغرافية
| العنوان: |
FIGURE 6 from Targeting Tryptophan Catabolism in Ovarian Cancer to Attenuate Macrophage Infiltration and PD-L1 Expression |
| المؤلفون: |
Lyndsey S. Crump, Jessica L. Floyd, Li-Wei Kuo, Miriam D. Post, Mike Bickerdike, Kathleen O'Neill, Kayla Sompel, Kimberly R. Jordan, Bradley R. Corr, Nicole Marjon, Elizabeth R. Woodruff, Jennifer K. Richer, Benjamin G. Bitler |
| سنة النشر: |
2024 |
| المجموعة: |
Smithsonian Institution: Figshare |
| مصطلحات موضوعية: |
Cancer, Molecular and Cellular Biology, Therapeutic Research and Development, Immuno-oncology, Gynecological Cancers, Ovarian cancer, Metabolism, Metabolic pathways, Drug Mechanisms, Cell cycle mechanisms of anticancer drug action, Immunology, Tumor immunology animal models, Immunomodulation |
| الوصف: |
IDO1/TDO2 inhibition combined with cisplatin attenuates cisplatin-induced PD-L1 and extends overall survival. A, COV504 treated for 48 hours with control, cisplatin (10 µmol/L), or cisplatin (10 µmol/L)/AT-0174 (5 µmol/L). PD-L1 expression was measured via flow cytometry. B, ID8 (Tp53 − / − ) syngeneic animal study with cisplatin (i.p., weekly, 0.5 mg/kg) and/or AT-0174 (oral gavage, daily, 120 mg/kg). n = 10 mice/group C ). Kaplan–Meier curve of animal study described in B. Error bars, SEM. Statistical test, multicomparison ANOVA (A) and log-rank (C). |
| نوع الوثيقة: |
still image |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/figure/FIGURE_6_from_Targeting_Tryptophan_Catabolism_in_Ovarian_Cancer_to_Attenuate_Macrophage_Infiltration_and_PD-L1_Expression/25429245 |
| DOI: |
10.1158/2767-9764.25429245.v1 |
| الاتاحة: |
https://doi.org/10.1158/2767-9764.25429245.v1 |
| Rights: |
CC BY |
| رقم الانضمام: |
edsbas.D1960566 |
| قاعدة البيانات: |
BASE |