Dissertation/ Thesis
Σύγκριση πλειοτροπικών δράσεων υπολιπιδαιμικών θεραπειών ; Comparison of pleiotropic effects of hypolipidemic drugs
| العنوان: | Σύγκριση πλειοτροπικών δράσεων υπολιπιδαιμικών θεραπειών ; Comparison of pleiotropic effects of hypolipidemic drugs |
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| المؤلفون: | Moutzouri, Elisavet, Μουτζούρη, Ελισάβετ |
| بيانات النشر: | University of Ioannina Πανεπιστήμιο Ιωαννίνων |
| سنة النشر: | 2015 |
| المجموعة: | National Archive of PhD Theses (National Documentation Centre Greece) |
| مصطلحات موضوعية: | Οξειδωτικό στρες, Φλεγμονή, Toll-like υποδοχείς, Στατίνες, Εζετιμίμπη, Πλειοτροπικές δράσεις, Λιποπρωτεϊνική φωσφολιπάση Α2, Oxidative stress, Inflammation, Toll-like receptors, Statins, Ezetimibe, Pleiotropic effects, Lipoprotein associated phospholipase A2, Ιατρική και Επιστήμες Υγείας, Βασική Ιατρική, Κλινική Ιατρική, Medical and Health Sciences, Basic Medicine, Clinical Medicine |
| الوصف: | Introduction: Statins may exhibit effects, which are independent of their lipidloweringeffects. Among them are anti-inflammatory, anti-oxidant effects, uric-acid loweringeffects as well as effects on glucose metabolism. Whether different statins at equivalentdoses (depending on their lipophilicity) or the combination of low-dose statin with ezetimibehave comparable pleiotropic effects is unknownAim: The aim οf this thesis was to compare the effects of different statins or thecombination of a statin with ezetimibe at equivalent low-density lipoprotein cholesterollowering doses on several inflammatory, oxidative stress, uric acid und glycemic parametersin subjects with hypercholesterolemia.Methods: Protocol 1. We enrolled one hundred and fifty three (n = 153)hypercholesterolemic subjects who were randomized to receive simvastatin 40 mg orsimvastatin/ezetimibe 10/10 mg or rosuvastatin 10 mg daily.We measured (at baseline and following 12 weeks of treatment):- Oxidative Stress parameters:1) Plasma 8-Epi prostaglandin F2 alpha (8-epiPGF2a)2) Oxidized LDL (oxLDL)- Inflammatory parameters:1) Lipoprotein associated phospholipase A2 (Lp-PLA2) activity and mass- Glucose metabolism parameters1) Homeostasis model assessment of insulin resistance (HOMA-IR),2) Fasting insulin levels,3) Fasting plasma glucose (FPG),4) Glycosylated hemoglobin (HbA1c),5) HOMA of β-cell function (HOMA-B)- Uric acid metabolism parameters1) Serum uric acid levels,2) Fractional excretion of uric acid,3) Renal function parametersProtocol 2: We enrolled sixty (n = 60) hypercholesterolemic subjects who wererandomized to receive either simvastatin 40 mg or simvastatin/ezetimibe 10/10 mg daily.We measured (at baseline and following 12 weeks of treatment):-ΤLR2 and TLR4 membrane expression in monocytes, LPS-induced intracellularproduction of IL-1β and IL-6 in both patient groups, as well as in 30 age- and sexmatchednormolipidemic controls.Results: Protocol 1: A significant reduction in plasma 8-isoprostane and oxLDL levelswas observed in all treatment ... |
| نوع الوثيقة: | doctoral or postdoctoral thesis |
| اللغة: | Greek, Modern (1453-) |
| Relation: | http://hdl.handle.net/10442/hedi/39629 |
| DOI: | 10.12681/eadd/39629 |
| الاتاحة: | http://hdl.handle.net/10442/hedi/39629 https://doi.org/10.12681/eadd/39629 |
| Rights: | BY |
| رقم الانضمام: | edsbas.D192988 |
| قاعدة البيانات: | BASE |
| DOI: | 10.12681/eadd/39629 |
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