Academic Journal
Autoimmune Thyroid Disease and Pregnancy: The Interaction Between Genetics, Epigenetics and Environmental Factors
| العنوان: | Autoimmune Thyroid Disease and Pregnancy: The Interaction Between Genetics, Epigenetics and Environmental Factors |
|---|---|
| المؤلفون: | Bogović Crnčić, Tatjana, Ćurko-Cofek, Božena, Batičić, Lara, Girotto, Neva, Tomaš, Maja Ilić, Kršek, Antea, Krištofić, Ines, Štimac, Tea, Perić, Ivona, Sotošek, Vlatka, Klobučar, Sanja |
| المصدر: | https://www.mdpi.com/2077-0383/14/1/190 ; Journal of Clinical Medicine ; Volume 14 ; Issue 1 ; ISSN 2077-0383 (Online. |
| سنة النشر: | 2025 |
| المجموعة: | Repository of the University of Rijeka |
| مصطلحات موضوعية: | BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti, BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences, autoimmune thyroid disease, Graves’ disease, Hashimoto’s thyroiditis, maternal-fetal health, pregnancy, thyroid dysfunction |
| الوصف: | Autoimmune thyroid disease (AITD) is the leading cause of thyroid dysfunction globally, characterized primarily by two distinct clinical manifestations: Hashimoto’s thyroiditis (HT) and Graves’ disease (GD). The prevalence of AITD is approximately twice as high in women compared to men, with a particularly pronounced risk during the reproductive years. Pregnancy exerts profound effects on thyroid physiology and immune regulation due to hormonal fluctuations and immune adaptations aimed at fostering maternal–fetal tolerance, potentially triggering or exacerbating AITD. The impact of AITD on pregnancy outcomes is multifaceted. Both HT and GD have been associated with adverse obstetric and neonatal outcomes, including miscarriage, preterm delivery, preeclampsia and fetal growth restriction. Inadequately managed AITD can also affect fetal neurodevelopment due to disrupted maternal thyroid hormone availability during critical periods of brain maturation. This review explores the complex interplay between the genetic, epigenetic and environmental factors that drive AITD during pregnancy, highlighting their roles in disease development and impacts on pregnancy outcomes. Gaining a deeper understanding of these mechanisms is crucial for improving diagnostic tools, treatment options and preventive measures to enhance the health and well-being of both the mother and the newborn. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | Sveučilište u Rijeci. Medicinski fakultet. Katedra za anesteziologiju, reanimatologiju, hitnu i intenzivnu medicinu.; University of Rijeka. Faculty of Medicine. Department of Anaesthesiology,reanimatology and Intensive Care.; Sveučilište u Rijeci. Medicinski fakultet. Katedra za fiziologiju, imunologiju i patofiziologiju.; University of Rijeka. Faculty of Medicine. Department of Physiology, Immunology and Pathophxsiology.; Sveučilište u Rijeci. Medicinski fakultet. Katedra za ginekologiju i opstetriciju.; University of Rijeka. Faculty of Medicine. Department of Gynaecology and Obstetrics.; Sveučilište u Rijeci. Medicinski fakultet. Katedra za internu medicinu.; University of Rijeka. Faculty of Medicine. Department of Internal Medicine.; Sveučilište u Rijeci. Medicinski fakultet. Katedra za medicinsku kemiju, biokemiju i kliničku kemiju.; University of Rijeka. Faculty of Medicine. Department of Chemistry and Biochemistry.; Sveučilište u Rijeci. Medicinski fakultet. Katedra za nuklearnu medicinu.; University of Rijeka. Faculty of Medicine. Department of Nuclear Medicine.; https://www.unirepository.svkri.uniri.hr/islandora/object/medri:9254; https://urn.nsk.hr/urn:nbn:hr:184:508639; https://www.unirepository.svkri.uniri.hr/islandora/object/medri:9254/datastream/FILE0 |
| الاتاحة: | https://www.unirepository.svkri.uniri.hr/islandora/object/medri:9254 https://urn.nsk.hr/urn:nbn:hr:184:508639 https://www.unirepository.svkri.uniri.hr/islandora/object/medri:9254/datastream/FILE0 |
| Rights: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.D175711D |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |