Academic Journal
Zebrafish as a Human Muscle Model for Studying Age-Dependent Sarcopenia and Frailty
| العنوان: | Zebrafish as a Human Muscle Model for Studying Age-Dependent Sarcopenia and Frailty |
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| المؤلفون: | Paula Aranda-Martínez, Ramy K. A. Sayed, José Fernández-Martínez, Yolanda Ramírez-Casas, Yang Yang, Germaine Escames, Darío Acuña-Castroviejo |
| المصدر: | International Journal of Molecular Sciences, Vol 25, Iss 11, p 6166 (2024) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2024 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | zebrafish, aging, skeletal muscle, mitochondria, sarcopenia, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Currently, there is an increase in the aging of the population, which represents a risk factor for many diseases, including sarcopenia. Sarcopenia involves progressive loss of mass, strength, and function of the skeletal muscle. Some mechanisms include alterations in muscle structure, reduced regenerative capacity, oxidative stress, mitochondrial dysfunction, and inflammation. The zebrafish has emerged as a new model for studying skeletal muscle aging because of its numerous advantages, including histological and molecular similarity to human skeletal muscle. In this study, we used fish of 2, 10, 30, and 60 months of age. The older fish showed a higher frailty index with a value of 0.250 ± 0.000 because of reduced locomotor activity and alterations in biometric measurements. We observed changes in muscle structure with a decreased number of myocytes (0.031 myocytes/μm 2 ± 0.004 at 60 months) and an increase in collagen with aging up to 15% ± 1.639 in the 60-month group, corresponding to alterations in the synthesis, degradation, and differentiation pathways. These changes were accompanied by mitochondrial alterations, such as a nearly 50% reduction in the number of intermyofibrillar mitochondria, 100% mitochondrial damage, and reduced mitochondrial dynamics. Overall, we demonstrated a similarity in the aging processes of muscle aging between zebrafish and mammals. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/25/11/6166; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067; https://doaj.org/article/251f972e3686420a90b4c09d7d34e363 |
| DOI: | 10.3390/ijms25116166 |
| الاتاحة: | https://doi.org/10.3390/ijms25116166 https://doaj.org/article/251f972e3686420a90b4c09d7d34e363 |
| رقم الانضمام: | edsbas.D15B5727 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms25116166 |