Academic Journal
Immunotherapy of Prostate Cancer with Genetically Enhanced Tumor-Specific T Cell Precursors
| العنوان: | Immunotherapy of Prostate Cancer with Genetically Enhanced Tumor-Specific T Cell Precursors |
|---|---|
| المؤلفون: | Brink, Marcel van den |
| المساهمون: | SLOAN-KETTERING INST FOR CANCER RESEARCH NEW YORK |
| المصدر: | DTIC |
| سنة النشر: | 2010 |
| المجموعة: | Defense Technical Information Center: DTIC Technical Reports database |
| مصطلحات موضوعية: | Anatomy and Physiology, Medicine and Medical Research, PROSTATE CANCER, IMMUNOTHERAPY, PRECURSORS, NEOPLASMS, REGIONS, ADAPTIVE SYSTEMS, THERAPY, TARGETING, RESPONSE(BIOLOGY), MICE, T LYMPHOCYTES, INOCULATION, IMMUNITY, TRANSPLANTATION, CHEMOTHERAPY, THYMUS, RADIATION, STRATEGY |
| الوصف: | Adaptive immunity can contribute significantly to tumor immunosurveillance and anti-tumor activity of cancer treatment regimens. We have reported previously that in vitro generated T cell precursors can be adoptively transferred across MHC barriers to allogeneic hosts and demonstrated that genetically engineered tumor-specific T cell precursors mediate enhanced anti-tumor responses. In this project we have proposed to generate genetically engineered prostate cancer-specific T cell precursors and test their efficacy for tumor immunotherapy in mouse models of prostate cancer. We now report that we have established non-myeloablative regimens to support engraftment of T cell precursors and established a prostate cancer model to test our adoptive therapy strategy. Non-myeloablative regimens were developed using a combination of radiation limited to the thymic region and cytoxan chemotherapy. The prostate cancer model (both localized and disseminated) was established using inoculation of RM1 cell line expressing human prostate specific membrane antigen (PSMA). We also report that we have optimized the transduction of T cell precursors with chimeric antigen receptor (CAR) targeting PSMA- pZ1. ; The original document contains color images. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| Relation: | http://www.dtic.mil/docs/citations/ADA542620 |
| الاتاحة: | http://www.dtic.mil/docs/citations/ADA542620 http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA542620 |
| Rights: | Approved for public release; distribution is unlimited. |
| رقم الانضمام: | edsbas.D152529B |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |