Academic Journal
Inositols: From Established Knowledge to Novel Approaches
| العنوان: | Inositols: From Established Knowledge to Novel Approaches |
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| المؤلفون: | Dinicola, S., Unfer, V., Facchinetti, F., Soulage, C. O., Greene, N. D., Bizzarri, M., Laganà, A. S., Chan, S. Y., Bevilacqua, A., Pkhaladze, L., Benvenga, S., Stringaro, A., Barbaro, D., Appetecchia, M., Aragona, C., Bezerra Espinola, M. S., Cantelmi, T., Cavalli, P., Chiu, T. T., Copp, A. J., d'Anna, R., Dewailly, D., Di Lorenzo, C., Diamanti-Kandarakis, E., Hernández Marín, I., Hod, M., Kamenov, Z., Kandaraki, E., Monastra, G., Montanino Oliva, M., Nestler, J. E., Nordio, M., Ozay, A. C., Papalou, O., Porcaro, G., Prapas, N., Roseff, S., Vazquez-Levin, M., Vucenik, I., Wdowiak, A. |
| المساهمون: | Systems Biology Group Lab Rome, Italy (SBGL), Azienda Ospedaleria Universitaria di Modena = University Hospital of Modena, Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University College of London London (UCL), Università degli Studi di Roma "La Sapienza" = Sapienza University Rome (UNIROMA), Universitá degli Studi dell’Insubria = University of Insubria Varese (Uninsubria), National University of Singapore (NUS), Zhordania and Khomasuridze Institute of Reproductology Tbilisi, Georgia (ZKIR), University of Messina, National Center for Drug Research and Evaluation Rome, Italy, Istituto Superiore di Sanità = National Institute of Health (ISS), Azienda Usl Toscana nord ovest (AUTNO), Regina Elena National Cancer Institute Rome, Institute for Interpersonal Cognitive Therapy Rome, Italy (2ICT), Istituto Clinico Humanitas Milan (IRCCS Milan), Humanitas University Milan (Hunimed), The Chinese University of Hong Kong Hong Kong (CUHK), Université de Lille, Hygeia Hospital, Universidad Nacional Autónoma de México = National Autonomous University of Mexico (UNAM), Tel Aviv University (TAU), Medical University of Sofia Bulgarie, Santo Spirito Hospital Athens, Greece (2SH), Virginia Commonwealth University (VCU), Azienda Sanitaria Locale ROMA (ASL), Near East University, USL UMBRIA Terni, Italy (USLU), IAKENTRO Thessaloniki, Greece, South Florida Institute for Reproductive Medicine Boca Raton, FL, USA (IVFMD), Instituto de Biología y Medicina Experimental Buenos Aires (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas Buenos Aires (CONICET), University of Maryland Baltimore, Medical University of Lublin |
| المصدر: | ISSN: 1661-6596. |
| بيانات النشر: | CCSD MDPI |
| سنة النشر: | 2021 |
| المجموعة: | Institut National de la Recherche Agronomique: ProdINRA |
| مصطلحات موضوعية: | D-chiro-Inositol, FSH, GDM, PCOS, aromatase, epimerase, myo-Inositol, neural tube defects, steroidogenesis, testosterone, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Myo-inositol (myo-Ins) and D-chiro-inositol (D-chiro-Ins) are natural compounds involved in many biological pathways. Since the discovery of their involvement in endocrine signal transduction, myo-Ins and D-chiro-Ins supplementation has contributed to clinical approaches in ameliorating many gynecological and endocrinological diseases. Currently both myo-Ins and D-chiro-Ins are well-tolerated, effective alternative candidates to the classical insulin sensitizers, and are useful treatments in preventing and treating metabolic and reproductive disorders such as polycystic ovary syndrome (PCOS), gestational diabetes mellitus (GDM), and male fertility disturbances, like sperm abnormalities. Moreover, besides metabolic activity, myo-Ins and D-chiro-Ins deeply influence steroidogenesis, regulating the pools of androgens and estrogens, likely in opposite ways. Given the complexity of inositol-related mechanisms of action, many of their beneficial effects are still under scrutiny. Therefore, continuing research aims to discover new emerging roles and mechanisms that can allow clinicians to tailor inositol therapy and to use it in other medical areas, hitherto unexplored. The present paper outlines the established evidence on inositols and updates on recent research, namely concerning D-chiro-Ins involvement into steroidogenesis. In particular, D-chiro-Ins mediates insulin-induced testosterone biosynthesis from ovarian thecal cells and directly affects synthesis of estrogens by modulating the expression of the aromatase enzyme. Ovaries, as well as other organs and tissues, are characterized by a specific ratio of myo-Ins to D-chiro-Ins, which ensures their healthy state and proper functionality. Altered inositol ratios may account for pathological conditions, causing an imbalance in sex hormones. Such situations usually occur in association with medical conditions, such as PCOS, or as a consequence of some pharmacological treatments. Based on the physiological role of inositols and the ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/34638926; PUBMED: 34638926; PUBMEDCENTRAL: PMC8508595; WOS: 000756356100002 |
| DOI: | 10.3390/ijms221910575 |
| الاتاحة: | https://inserm.hal.science/inserm-03834381 https://inserm.hal.science/inserm-03834381v1/document https://inserm.hal.science/inserm-03834381v1/file/ijms-22-10575-v2.pdf https://doi.org/10.3390/ijms221910575 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.D1457AB0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms221910575 |
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