Academic Journal
NIR-Mediated drug release and tumor theranostics using melanin-loaded liposomes
| العنوان: | NIR-Mediated drug release and tumor theranostics using melanin-loaded liposomes |
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| المؤلفون: | Kim, Min Ah., Lee, Chang-Moon |
| المساهمون: | National Research Foundation |
| المصدر: | Biomaterials Research ; volume 26, issue 1 ; ISSN 2055-7124 |
| بيانات النشر: | American Association for the Advancement of Science (AAAS) |
| سنة النشر: | 2022 |
| الوصف: | Background Heat generation in a drug delivery carrier by exposure to near-infrared (NIR) light with excellent tissue transmittance is an effective strategy for drug release and tumor therapy. Because liposomes have amphiphilic properties, they are useful as drug carriers. Liposomes are also very suitable for drug delivery strategies using heat generation by NIR laser because lipid bilayers are easily broken by heat. Thermally generated bubbles from liposomes not only induce drug release, but also enable ultrasound imaging. Methods Melanin, perfluorohexane (PFH), and 5-fluorouracil (5-FU)-loaded liposomes (melanin@PFH@5-FU-liposomes) that can generate heat and bubble by NIR laser irradiation were prepared by a thin film method. Conversion of light to heat and bubble generation of melanin@PFH@5-FU-liposomes were evaluated using an infrared (IR) thermal imaging camera and an ultrasound imaging system both in vitro and in vivo . To investigate tumor therapeutic effect, NIR laser of 808 nm was used to irradiate tumor site for 10 min after injecting melanin@PFH@5-FU-liposome into tail veins of CT26-bearing mice. Results Melanin@PFH@5-FU-liposomes showed a spherical shape with a size of 209.6 ± 4.3 nm. Upon NIR laser irradiation, melanin@PFH@5-FU-liposomes exhibited effective temperature increase both in vitro and in vivo . In this regard, temperature increase caused a phase transition of PFH to induce bubble generation dramatically, resulting in effective drug release behavior and ultrasound imaging. The temperature of the tumor site was increased to 52 t and contrast was greatly enhanced during ultrasound imaging due to the generation of bubble. More importantly, tumor growth was effectively inhibited by injection of melanin@PFH@5-FU-liposomes with laser irradiation. Conclusions Based on intrinsic photothermal properties of melanin and phase transition properties of PFH, melanin@PFH@5-FU-liposomes exhibited effective heat and bubble generation upon NIR laser irradiation. The elevated temperature induced ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1186/s40824-022-00270-w |
| DOI: | 10.1186/s40824-022-00270-w.pdf |
| DOI: | 10.1186/s40824-022-00270-w/fulltext.html |
| الاتاحة: | https://doi.org/10.1186/s40824-022-00270-w https://link.springer.com/content/pdf/10.1186/s40824-022-00270-w.pdf https://link.springer.com/article/10.1186/s40824-022-00270-w/fulltext.html https://spj.science.org/doi/pdf/10.1186/s40824-022-00270-w |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.D1164C01 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s40824-022-00270-w |
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