Academic Journal
Traumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model
| العنوان: | Traumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model |
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| المؤلفون: | Bottom-Tanzer, Samantha, Corella, Sofia, Meyer, Jochen, Sommer, Mary, Bolaños, Luis, Murphy, Timothy, Quiñones, Sadi, Heiney, Shane, Shtrahman, Matthew, Whalen, Michael, Oren, Rachel, Higley, Michael J, Cardin, Jessica A, Noubary, Farzad, Armbruster, Moritz, Dulla, Chris |
| المساهمون: | American Epilepsy Society, U.S. Department of Defense, National Institute of Neurological Disease and Stroke |
| المصدر: | Cerebral Cortex ; volume 34, issue 2 ; ISSN 1047-3211 1460-2199 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2024 |
| الوصف: | Traumatic brain injury (TBI) is the leading cause of death in young people and can cause cognitive and motor dysfunction and disruptions in functional connectivity between brain regions. In human TBI patients and rodent models of TBI, functional connectivity is decreased after injury. Recovery of connectivity after TBI is associated with improved cognition and memory, suggesting an important link between connectivity and functional outcome. We examined widespread alterations in functional connectivity following TBI using simultaneous widefield mesoscale GCaMP7c calcium imaging and electrocorticography (ECoG) in mice injured using the controlled cortical impact (CCI) model of TBI. Combining CCI with widefield cortical imaging provides us with unprecedented access to characterize network connectivity changes throughout the entire injured cortex over time. Our data demonstrate that CCI profoundly disrupts functional connectivity immediately after injury, followed by partial recovery over 3 weeks. Examining discrete periods of locomotion and stillness reveals that CCI alters functional connectivity and reduces theta power only during periods of behavioral stillness. Together, these findings demonstrate that TBI causes dynamic, behavioral state-dependent changes in functional connectivity and ECoG activity across the cortex. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/cercor/bhae038 |
| الاتاحة: | http://dx.doi.org/10.1093/cercor/bhae038 https://academic.oup.com/cercor/article-pdf/34/2/bhae038/56670981/bhae038.pdf |
| Rights: | https://academic.oup.com/pages/standard-publication-reuse-rights |
| رقم الانضمام: | edsbas.D0EF2780 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/cercor/bhae038 |
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