Academic Journal
Therapeutic efficacy of two tear supplements in the management of dry eye disease in Saudi Arabia: The Twaiq Mountain Eye Study II
| العنوان: | Therapeutic efficacy of two tear supplements in the management of dry eye disease in Saudi Arabia: The Twaiq Mountain Eye Study II |
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| المؤلفون: | AlShammeri, Saleh, AlKhaldi, Saleh A., AlMutairi, Reem T., AlZamil, Hamad A., AlJohani, Saad M., AlJohani, Saeed, AlDakhil, Sulaiman |
| المصدر: | Saudi Journal of Ophthalmology ; ISSN 1319-4534 2542-6680 |
| بيانات النشر: | Medknow |
| سنة النشر: | 2024 |
| الوصف: | PURPOSE: Comparison of the effectiveness between a lipid-based (Cationorm ® [CTN]) and nonlipid-based (Artelac Advanced ® , 0.2% sodium hyaluronate [SH]) tear supplements in the management of dry eye disease. METHODS: This was a randomized, single-masked study (0.2% SH vs. lipid-based eye drops) in two parallel groups over 4 weeks. n = 44 patients were evaluated. The outcome of the tear supplements on the ocular surface symptoms, tear meniscus height (TMH), noninvasive tear break-up time (NITBUT), lipid layer thickness (LLT), corneal and conjunctival redness, and strip meniscometry tube (SMTube) were measured after 4 weeks, compared to baseline. RESULTS: Compared to the baseline, a lipid-based (CTN) eye drop achieved a significant reduction in symptoms (14.25 ± 12.70 vs. 38.60 ± 23.13 score, n = 22 patients) at 4 weeks; Artelac Advanced ® , 0.2% SH and CTN showed an improvement in TMH, but it was statistically significant improved in CTN group in compared to 0.2% SH group. Statistical analysis showed improvement in NITBUT and corneal and conjunctival redness in both treatment groups. At 4 weeks, the LLT had further increased in Artelac Advanced ® , 0.2% SH group. Both eye drops did not change the tear production measured by SMTube after 4 weeks. CONCLUSION: Both lipid-based (CTN) and nonlipid-based Artelac Advanced ® , 0.2% SH eye drops effectively improved tear volume, tear film stability, and ocular surface health. In addition, lipid-based CTN significantly decreased dry eye symptoms compared to Artelac Advanced ® , 0.2% SH. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.4103/sjopt.sjopt_305_23 |
| الاتاحة: | https://doi.org/10.4103/sjopt.sjopt_305_23 https://journals.lww.com/10.4103/sjopt.sjopt_305_23 |
| رقم الانضمام: | edsbas.D0A1FDF3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.4103/sjopt.sjopt_305_23 |
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