التفاصيل البيبلوغرافية
| العنوان: |
Inmunotipificación y cuantificacion de cadenas ligeras libres en pacientes ecuatorianos con Gammapatías monoclonales |
| المؤلفون: |
Howland Alavarez, Ivon |
| المصدر: |
Revista Ecuatoriana de Medicina y Ciencias Biológicas: REMCB, ISSN 2477-9113, Vol. 42, Nº. 2, 2021, pags. 123-132 |
| سنة النشر: |
2021 |
| المجموعة: |
Dialnet - Portada de revistas (Universidad de La Rioja) |
| مصطلحات موضوعية: |
monoclonal gammopathy, monoclonal component, protein electrophoresis, immunotyping, free light chains, gammapatía monoclonal, componente monoclonal, electroforesis de proteína, inmunotipificación, cadenas ligeras libres, Hematología oncológica |
| الوصف: |
At present, some of the hematological neoplasms, among them monoclonal gammopathies (MG), are incurable despite advances in oncological therapies. Studies of MG in Ecuador are scarce; the latest statistics show that multiple myeloma (MM) is among the top 25 tumors in the country. In order to characterize the results of immunotyping (IT) and quantification of free light chains in blood (FLC) of patients with MG in Portoviejo, Manabí; Ecuador, an observational, descriptive, longitudinal and retrospective study was carried out that included 237protein electrophoresis (PEL), 42 IT and 58 FLC, from patients seen in Hematology Services of the region from January to July 2019. The techniques were used by Sebia ELP and IT and by Seralite. 14% of the ELP studied were GM, the majority male with an average age of 64 years and a range of 31-87 years. More than half of the GM had a diagnosis of Multiple Myeloma (MM) of which 15 % were under 40 years of age. 69% of IT were positive and the IgG kappa (κ) isotype predominated. IT did not show diagnostic utility in non-secretory or oligosecretory MM cases. 91% of the FLC presented pathological results of a κ / λ relationship. The FLC results were significantly higher than those reported by the technique traditionally used in the total light chain region, so this test increased the possibility of detection of MM in all its variants. ; En la actualidad algunas de las neoplasias hematológicas, entre ellas las gammapatías monoclonales (GM) son incurables a pesar de los avances en las terapias oncológicas. Los estudios de GM en Ecuador son escasos; en las últimas estadísticas se muestra que el mieloma múltiple (MM) se encuentra entre los primeros 25 tumores en el país. Las pruebas de diagnóstico más utilizadas son electroforesis y cadenas ligeras Con el objetivo de caracterizar los resultados en suero de electroforesis de proteínas (ELP), inmunotipificación (IT) y cuantificación de cadenas ligeras libres en sangre (CLL) de pacientes con GM en Portoviejo, Manabí; Ecuador, se realizó ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
Spanish; Castilian |
| Relation: |
https://dialnet.unirioja.es/servlet/oaiart?codigo=8575341; (Revista) ISSN 2477-9148; (Revista) ISSN 2477-9113 |
| الاتاحة: |
https://dialnet.unirioja.es/servlet/oaiart?codigo=8575341 |
| Rights: |
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| رقم الانضمام: |
edsbas.D05ECDED |
| قاعدة البيانات: |
BASE |