Academic Journal
Substrains of inbred mice differ in their physical activity as a behavior
| العنوان: | Substrains of inbred mice differ in their physical activity as a behavior |
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| المؤلفون: | Coletti, D, BERARDI, Emanuele, Aulino, P, Rossi, E, Moresi, V, Li, ZL, Adamo, S |
| المساهمون: | orcid:0000-0002-0775-9605 |
| بيانات النشر: | HINDAWI LTD |
| سنة النشر: | 2021 |
| المجموعة: | Document Server@UHasselt (Universiteit Hasselt) |
| الوصف: | Recent studies strengthen the belief that physical activity as a behavior has a genetic basis. Screening wheel-running behavior in inbred mouse strains highlighted differences among strains, showing that even very limited genetic differences deeply affect mouse behavior. We extended this observation to substrains of the same inbred mouse strain, that is, BALB/c mice. We found that only a minority of the population of one of these substrains, the BALB/c J, performs spontaneous physical activity. In addition, the runners of this substrain cover a significantly smaller distance than the average runners of two other substrains, namely, the BALB/c ByJ and the BALB/c AnNCrl. The latter shows a striking level of voluntary activity, with the average distance run/day reaching up to about 12 kilometers. These runners are not outstanders, but they represent the majority of the population, with important scientific and economic fallouts to be taken into account during experimental planning. Spontaneous activity persists in pathological conditions, such as cancer-associated cachexia. This important amount of physical activity results in a minor muscle adaptation to endurance exercise over a three-week period; indeed, only a nonsignificant increase in NADH transferase+ fibers occurs in this time frame. ; D. Coletti is supported by UPMC Emergence 2011 and by AFM 2012. Z. Li is supported by ANR and by AFM. PRIN 2009 (Project no. 2009WBFZYM 001) and Italian Space Agency (ASI), OSMA project, grant to S. Adamo are also acknowledged. The authors are indebted to Carla Ramina for her precious technical assistance. They gratefully thank Richard Lowry, Ph.D., Professor of Psychology Emeritus at the Vassar College for his web-based, user-friendly tool for performing statistical computation, VassarStats, which They used for statistical analysis. The mice used throughout this study were a generous gift of Janvier SAS (Le Genest St Isle, St Berthevin Cedex, France). |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | TheScientificWorldjournal, 2013 (Art N° 237260); http://hdl.handle.net/1942/33217; 2013; WOS:000316146800001; http://europepmc.org/articles/PMC3606797 |
| DOI: | 10.1155/2013/237260 |
| الاتاحة: | http://hdl.handle.net/1942/33217 https://doi.org/10.1155/2013/237260 http://europepmc.org/articles/PMC3606797 |
| رقم الانضمام: | edsbas.D01A6F7B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1155/2013/237260 |
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