Academic Journal
Direct Effect of Bevacizumab on Glioblastoma Cell Lines In Vitro
| العنوان: | Direct Effect of Bevacizumab on Glioblastoma Cell Lines In Vitro |
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| المؤلفون: | Simon, Thomas, Coquerel, Bérénice, Petit, Alexandre, Kassim, Yusra, Demange, Elise, Le Cerf, Didier, Perrot, Valérie, Vannier, Jean-Pierre |
| المساهمون: | Micro-Environnement et Régulation Cellulaire Intégrée (MERCI), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Polymères Biopolymères Surfaces (PBS), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Institut Normand de Chimie Moléculaire Médicinale et Macromoléculaire (INC3M), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | ISSN: 1535-1084 ; NeuroMolecular Medicine ; https://normandie-univ.hal.science/hal-01869051 ; NeuroMolecular Medicine, 2014, 16 (4), pp.752 - 771. ⟨10.1007/s12017-014-8324-8⟩. |
| بيانات النشر: | HAL CCSD Humana Press |
| سنة النشر: | 2014 |
| المجموعة: | Normandie Université: HAL |
| مصطلحات موضوعية: | Anti-angiogenic therapies, Autocrine loop, Brain extracellular matrix, Glioblastoma, VEGF-A, [CHIM.POLY]Chemical Sciences/Polymers, [CHIM.MATE]Chemical Sciences/Material chemistry |
| الوصف: | International audience ; Bevacizumab is a humanized monoclonal antibody directed against the pro-angiogenic factor vascular and endothelial growth factor-A (VEGF-A) used in the treatment of glioblastomas. Although most patients respond initially to this treatment, studies have shown that glioblastomas eventually recur. Several non-mutually exclusive theories based on the anti-angiogenic effect of bevacizumab have been proposed to explain these mechanisms of resistance. In this report, we studied whether bevacizumab can act directly on malignant glioblastoma cells. We observe changes in the expression profiles of components of the VEGF/VEGF-R pathway and in the response to a VEGF-A stimulus following bevacizumab treatment. In addition, we show that bevacizumab itself acts on glioblastoma cells by activating the Akt and Erks survival signaling pathways. Bevacizumab also enhances proliferation and invasiveness of glioblastoma cells in hyaluronic acid hydrogel. We propose that the paradoxical effect of bevacizumab on glioblastoma cells could be due to changes in the VEGF-A-dependent autocrine loop as well as in the intracellular survival pathways, leading to the enhancement of tumor aggressiveness. Investigation of how bevacizumab interacts with glioblastoma cells and the resulting downstream signaling pathways will help targeting populations of resistant glioblastoma cells. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | hal-01869051; https://normandie-univ.hal.science/hal-01869051 |
| DOI: | 10.1007/s12017-014-8324-8 |
| الاتاحة: | https://normandie-univ.hal.science/hal-01869051 https://doi.org/10.1007/s12017-014-8324-8 |
| رقم الانضمام: | edsbas.D00718A0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s12017-014-8324-8 |
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