Academic Journal
Caplacizumab for treating subacute intra-stent thrombus occurring despite efficacious double anti-platelet treatment and anticoagulation: a case report.
| العنوان: | Caplacizumab for treating subacute intra-stent thrombus occurring despite efficacious double anti-platelet treatment and anticoagulation: a case report. |
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| المؤلفون: | Stalder, G., Chatte, A., De Rossi, N., Yerly, P., Alberio, L., Eeckhout, E. |
| المساهمون: | Vrachatis, Dimitrios A (ed.), Gragnano, Felice (ed.), Hartley, Adam (ed.), Cankovic, Milenko Zoran (ed.), Spinthakis, Nikolaos (ed.), Waight, Michael (ed.) |
| المصدر: | European heart journal. Case reports, vol. 7, no. 2, pp. ytac497 |
| سنة النشر: | 2023 |
| المجموعة: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| مصطلحات موضوعية: | Cardiology and Cardiovascular Medicine, Caplacizumab, Case Report, N-acetylcysteine, STEMI, Subacute stent thrombosis, von Willebrand factor |
| الوصف: | Acute and subacute stent thromboses are a rare complication associated with high mortality and morbidity occurring in ∼1.5% of patients treated with primary percutaneous intervention for ST-elevation myocardial infarction (STEMI). Recent publications describe a potential role of the von Willebrand factor (VWF) in thrombus formation at sites of critical coronary stenosis in STEMI. We describe a 58-year-old woman with STEMI at initial presentation, who suffered subacute stent thrombosis despite good stent expansion, efficacious dual antiplatelet therapy, and therapeutic anticoagulation. Because of very high VWF values, we administered N-acetylcysteine in order to depolymerize VWF, but the drug was not well tolerated. Since the patient was still symptomatic, we used caplacizumab in order to prevent VWF from interacting with platelets. Under this treatment, the clinical and angiographic course was favourable. Considering a modern view of intracoronary thrombus pathophysiology, we describe an innovative treatment approach, which eventually ended in a favourable outcome. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/36793934; info:eu-repo/semantics/altIdentifier/eissn/2514-2119; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_18F8C049C7960; https://serval.unil.ch/notice/serval:BIB_18F8C049C796; https://serval.unil.ch/resource/serval:BIB_18F8C049C796.P001/REF.pdf |
| DOI: | 10.1093/ehjcr/ytac497 |
| الاتاحة: | https://serval.unil.ch/notice/serval:BIB_18F8C049C796 https://doi.org/10.1093/ehjcr/ytac497 https://serval.unil.ch/resource/serval:BIB_18F8C049C796.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_18F8C049C7960 |
| Rights: | info:eu-repo/semantics/openAccess ; CC BY-NC 4.0 ; https://creativecommons.org/licenses/by-nc/4.0/ |
| رقم الانضمام: | edsbas.CFF9F6D8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ehjcr/ytac497 |
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