Academic Journal
Functional neurological restoration of amputated peripheral nerve using biohybrid regenerative bioelectronics.
| العنوان: | Functional neurological restoration of amputated peripheral nerve using biohybrid regenerative bioelectronics. |
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| المؤلفون: | Rochford, Amy E, Carnicer-Lombarte, Alejandro, Kawan, Malak, Jin, Amy, Hilton, Sam, Curto, Vincenzo F, Rutz, Alexandra L, Moreau, Thomas, Kotter, Mark RN, Malliaras, George G, Barone, Damiano G |
| المصدر: | essn: 2375-2548 ; nlmid: 101653440 |
| بيانات النشر: | American Association for the Advancement of Science (AAAS) //dx.doi.org/10.1126/sciadv.add8162 Sci Adv |
| سنة النشر: | 2023 |
| المجموعة: | Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: | Rats, Humans, Animals, Peripheral Nerves, Electrodes, Neurons, Nerve Regeneration |
| الوصف: | The development of neural interfaces with superior biocompatibility and improved tissue integration is vital for treating and restoring neurological functions in the nervous system. A critical factor is to increase the resolution for mapping neuronal inputs onto implants. For this purpose, we have developed a new category of neural interface comprising induced pluripotent stem cell (iPSC)-derived myocytes as biological targets for peripheral nerve inputs that are grafted onto a flexible electrode arrays. We show long-term survival and functional integration of a biohybrid device carrying human iPSC-derived cells with the forearm nerve bundle of freely moving rats, following 4 weeks of implantation. By improving the tissue-electronics interface with an intermediate cell layer, we have demonstrated enhanced resolution and electrical recording in vivo as a first step toward restorative therapies using regenerative bioelectronics. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://www.repository.cam.ac.uk/handle/1810/348786 |
| DOI: | 10.17863/CAM.96212 |
| الاتاحة: | https://www.repository.cam.ac.uk/handle/1810/348786 https://doi.org/10.17863/CAM.96212 |
| Rights: | Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.CFF80EFE |
| قاعدة البيانات: | BASE |
| DOI: | 10.17863/CAM.96212 |
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