التفاصيل البيبلوغرافية
| العنوان: |
Synthesis and Evaluation of 1,3,5-Triaryl-2-Pyrazoline Derivatives as Potent Dual Inhibitors of Urease and α-Glucosidase Together with Their Cytotoxic, Molecular Modeling and Drug-Likeness Studies |
| المؤلفون: |
Rabia Mehmood (5076536), Amina Sadiq (1951162), Reem I. Alsantali (9030215), Ehsan Ullah Mughal (9286830), Meshari A. Alsharif (11966591), Nafeesa Naeem (9286836), Asif Javid (9286839), Munirah M. Al-Rooqi (11966594), Gul-e-Saba Chaudhry (11857019), Saleh A. Ahmed (2514670) |
| سنة النشر: |
1753 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biochemistry, Medicine, Pharmacology, Biotechnology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, good adme profiles, 37 ± 0, 36 ± 0, 13 ± 0, 2q , 2o , 2m , 2l , 2i ,, 94 ± 1, 82 ± 1, 57 ± 1, 52 ± 1, 26 ± 1, like characteristics due, 42 ± 0, 76 μm ), 26 μm ), potent dual inhibitors, dual potent inhibitor, 50 , 13 , pyrazolines (< b, glucosidase inhibitory activity |
| الوصف: |
In the present work, a concise library of 1,3,5-triaryl-2-pyrazolines ( 2a–2q ) was designed and synthesized by employing a multistep strategy, and the newly synthesized compounds were screened for their urease and α-glucosidase inhibitory activities. The compounds ( 2a–2q ) were characterized using a combination of several spectroscopic techniques including FT-IR, 1 H NMR, 13 C NMR, and EI-MS. All the synthesized compounds, except compound 2i, were potent against urease as compared to the standard inhibitor thiourea (IC 50 = 21.37 ± 0.26 μM). These analogs disclosed varying degrees of urease inhibitory activities ranging from 9.13 ± 0.25 to 18.42 ± 0.42 μM. Compounds 2b, 2g, 2m , and 2q having IC 50 values of 9.36 ± 0.27, 9.13 ± 0.25, 9.18 ± 0.35, and 9.35 ± 0.35 μM, respectively, showed excellent inhibitory activity as compared to standard thiourea (IC 50 = 21.37 ± 0.26 μM). A kinetic study of compound 2g revealed that compound 2g inhibited urease in a competitive mode. Among the synthesized pyrazolines, the compounds 2c, 2k, 2m , and 2o exhibited excellent α-glucosidase inhibitory activity with the lowest IC 50 values of 212.52 ± 1.31, 237.26 ± 1.28, 138.35 ± 1.32, and 114.57 ± 1.35 μM, respectively, as compared to the standard acarbose (IC 50 = 375.82 ± 1.76 μM). The compounds ( 2a–2q) showed α-glucosidase IC 50 values in the range of 114.57 ± 1.35 to 462.94 ± 1.23 μM. Structure–activity relationship revealed that the size and electron-donating or -withdrawing effects of substituents influenced the activities, which led to the urease and α-glucosidase inhibiting properties. Compound 2m was a dual potent inhibitor against urease and α-glucosidase due to the presence of 2-CF 3 electron-withdrawing functionality on the phenyl ring. To the best of our knowledge, these synthetic compounds were found to be the most potent dual inhibitors of urease and α-glucosidase with minimum IC 50 values. The cytotoxicity of the compounds ( 2a–2q ) was also investigated against human cell lines MCF-7 and HeLa. Compound 2l ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/Synthesis_and_Evaluation_of_1_3_5-Triaryl-2-Pyrazoline_Derivatives_as_Potent_Dual_Inhibitors_of_Urease_and_-Glucosidase_Together_with_Their_Cytotoxic_Molecular_Modeling_and_Drug-Likeness_Studies/18812030 |
| DOI: |
10.1021/acsomega.1c06694.s001 |
| الاتاحة: |
https://doi.org/10.1021/acsomega.1c06694.s001 |
| Rights: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.CFE8FCB4 |
| قاعدة البيانات: |
BASE |