التفاصيل البيبلوغرافية
| العنوان: |
Decoding global transcriptional regulation during the early activation of Jurkat T cells by profiling intron-based TF activities. |
| المؤلفون: |
Yan Wu (70890), Lingfeng Xue (11347638), Wen Huang (186929), Minghua Deng (51065), Yihan Lin (115246) |
| سنة النشر: |
2022 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biochemistry, Cell Biology, Genetics, Developmental Biology, Cancer, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, +activities%22">xlink "> activities, tf activities inferred, estimated tf activities, limited temporal accuracy, series transcriptome data, proposed approach would, tf activities, series rna, seq data, temporal phasing, temporal control, transcription factors, temporally modulated, recent developments, level information, intronic reads, including development, dynamic processes, circadian rhythm, cell activation, broadly applicable, bioinformatic tools |
| الوصف: |
(A) Schematic of our experimental design. Time-series RNA-seq data were acquired during early Jurkat T cell activation. Each time point has two replicates. (B) Hierarchical clustering uncovered two functionally and dynamically distinct TF modules. Clustering was performed based on the Pearson correlation between intron-based TFAs. Two TF modules are indicated by dashed boxes. Three most enriched GO biological process terms for each module are shown. Intron-based TFA dynamics after z-score normalization of each TF are shown on the right. Note that only TFs with non-zero expression values were included in the analysis ( Materials and Methods ), and TF symbols are ordered from top to bottom, then left to right. See also S5 Fig for analogous analyses using exon-based and total reads-based methods. |
| نوع الوثيقة: |
still image |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/figure/Decoding_global_transcriptional_regulation_during_the_early_activation_of_Jurkat_T_cells_by_profiling_intron-based_TF_activities_/18129952 |
| DOI: |
10.1371/journal.pcbi.1009762.g004 |
| الاتاحة: |
https://doi.org/10.1371/journal.pcbi.1009762.g004 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.CFC3AD88 |
| قاعدة البيانات: |
BASE |