Academic Journal
Ether Lipid-Mediated Antioxidant Defense in Alzheimer’s Disease
| العنوان: | Ether Lipid-Mediated Antioxidant Defense in Alzheimer’s Disease |
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| المؤلفون: | Jové Font, Mariona, Mota Martorell, Natàlia, Obis Monné, Èlia, Sol, Joaquim, Martín Garí, Meritxell, Ferrer, Isidre, Portero Otín, Manuel, Pamplona Gras, Reinald |
| بيانات النشر: | MDPI |
| سنة النشر: | 2023 |
| المجموعة: | Universitat de Lleida: Repositori Obert UdL |
| مصطلحات موضوعية: | Antioxidants, Lipidomics, Lipid oxidation, Human brain, Neurodegeneration, Plasmalogens |
| الوصف: | One of the richest tissues in lipid content and diversity of the human body is the brain. The human brain is constitutively highly vulnerable to oxidative stress. This oxidative stress is a determinant in brain aging, as well as in the onset and progression of sporadic (late-onset) Alzheimer’s disease (sAD). Glycerophospholipids are the main lipid category widely distributed in neural cell membranes, with a very significant presence for the ether lipid subclass. Ether lipids have played a key role in the evolution of the human brain compositional specificity and functionality. Ether lipids determine the neural membrane structural and functional properties, membrane trafficking, cell signaling and antioxidant defense mechanisms. Here, we explore the idea that ether lipids actively participate in the pathogenesis of sAD. Firstly, we evaluate the quantitative relevance of ether lipids in the human brain composition, as well as their role in the human brain evolution. Then, we analyze the implications of ether lipids in neural cell physiology, highlighting their inherent antioxidant properties. Finally, we discuss changes in ether lipid content associated with sAD and their physiopathological implications, and propose a mechanism that, as a vicious cycle, explains the potential significance of ether lipids in sAD. ; Research by the authors was supported by the Spanish Ministry of Science, Innovation, and Universities (grants RTI2018-099200-B-I00 and PID2022-143140OB-I00), the Diputació de Lleida (PP10605—PIRS2021), and the Generalitat of Catalonia: Agency for Management of University and Research Grants (2021SGR00990) and Department of Health (SLT002/16/00250) to RP. This study has been co-financed by FEDER funds from the European Union (“A way to build Europe”). IRBLleida is a CERCA Programme/Generalitat of Catalonia. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2076-3921 |
| Relation: | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-099200-B-I00/ES/NEUROLIPIDOMICA DEL ENVEJECIMIENTO CEREBRAL HUMANO/; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica, Técnica y de Innovación 2021-2023/PID2022-143140OB-I00/ES/; Reproducció del document publicat a https://doi.org/10.3390/antiox12020293; Antioxidants, 2023, vol. 12, núm. 2, 293; https://doi.org/10.3390/antiox12020293; https://repositori.udl.cat/handle/10459.1/464340 |
| DOI: | 10.3390/antiox12020293 |
| الاتاحة: | https://doi.org/10.3390/antiox12020293 https://repositori.udl.cat/handle/10459.1/464340 |
| Rights: | cc-by (c) Mariona Jové et al., 2023 ; Attribution 4.0 International ; info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.CFBE9E7A |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20763921 |
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| DOI: | 10.3390/antiox12020293 |