Academic Journal
Immunogenicity in Peruvian volunteers of a booster dose of oral cholera vaccine consisting of whole cells plus recombinant B subunit
| العنوان: | Immunogenicity in Peruvian volunteers of a booster dose of oral cholera vaccine consisting of whole cells plus recombinant B subunit |
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| المؤلفون: | Begue, R E, Castellares, G, Cabezas, C, Sanchez, J L, Meza, R, Watts, D M, Taylor, D N |
| المصدر: | Infection and Immunity ; volume 63, issue 9, page 3726-3728 ; ISSN 0019-9567 1098-5522 |
| بيانات النشر: | American Society for Microbiology |
| سنة النشر: | 1995 |
| الوصف: | Forty-nine subjects received two doses of oral cholera vaccine consisting of whole cells plus recombinant B subunit; this was followed by a booster dose one year later. After the primary series, a significant (greater than twofold) increase in the levels of vibriocidal, anti-cholera toxin immunoglobulin G and anti-cholera toxin immunoglobulin A antibodies occurred in 54, 88, and 81% of the subjects, respectively. Within one year, titers decreased to levels close to baseline. A booster dose then induced rises to those which occurred after the initial vaccination. The results suggest that 1-year booster doses may be necessary to maintain immunity against cholera in Latin America. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1128/iai.63.9.3726-3728.1995 |
| الاتاحة: | http://dx.doi.org/10.1128/iai.63.9.3726-3728.1995 https://journals.asm.org/doi/pdf/10.1128/iai.63.9.3726-3728.1995 |
| Rights: | https://journals.asm.org/non-commercial-tdm-license |
| رقم الانضمام: | edsbas.CFA1960F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1128/iai.63.9.3726-3728.1995 |
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