Dissertation/ Thesis
A comparative study of the involvement of dietary proteins in energy homeostasis ; Etude comparative de l'implication des protéines alimentaires dans l'homéostasie énergétique
| العنوان: | A comparative study of the involvement of dietary proteins in energy homeostasis ; Etude comparative de l'implication des protéines alimentaires dans l'homéostasie énergétique |
|---|---|
| المؤلفون: | Fleury, Léa |
| المساهمون: | BioEcoAgro - Equipe 7 - Health benefit of protein hydrolysates and agro-food co-products: control of production, characterization and valorisation, BioEcoAgro - UMR transfrontalière INRAe - UMRT1158, Université d'Artois (UA)-Université de Liège-Université de Picardie Jules Verne (UPJV)-Université du Littoral Côte d'Opale (ULCO)-Université de Lille-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Université d'Artois (UA)-Université de Liège-Université de Picardie Jules Verne (UPJV)-Université du Littoral Côte d'Opale (ULCO)-Université de Lille-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Institut Charles Viollette (ICV) - ULR 7394 (ICV), Université d'Artois (UA)-Université du Littoral Côte d'Opale (ULCO)-Institut Supérieur d'Agriculture-Université de Lille-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Lille, Rozenn Ravallec, Benoit Cudennec |
| المصدر: | https://hal.science/tel-04550693 ; Sciences du Vivant [q-bio]. Université de Lille, 2022. Français. ⟨NNT : 2022ULILR028⟩. |
| بيانات النشر: | CCSD |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Intestinal glucose uptake, Regulation of food intake, In vitro digestion, Dietary proteins, Gastro-Intestinal hormones, DPP-IV, Hormones gastrointestinales, Satiété, Dipeptidylpeptidase IV, Absorption intestinale, Glucose, Bioénergétique, Protéines dans l'alimentation humain, digestion invitro, Protéines agroalimentaires, Prise alimentaire, [SDV]Life Sciences [q-bio] |
| الوصف: | In addition to being a source of essential nutrients for our body, dietary proteins participate in the regulation of energy homeostasis. In a context of obesity epidemic and food overconsumption, the characterization of the role of proteins on health becomes crucial. In general, proteins are known to reduce food intake by stimulating satiety and improving glucose homeostasis, but very few studies have focused on comparing the effects of protein origin on these phenomena. The objective of this work is to compare proteins of different origins on certain homeostasis mechanisms involved in the peripheral regulation of food intake and glucose metabolism. Proteins from various sources of animal or plant origin were thus selected: bovine hemoglobin, caseins, ovalbumin, whey, fish gelatin, peas and gluten. These proteins were first studied and compared in vivo in rats. A first study using metabolic cages determined the effect of proteins on short-term food intake, energy expenditure, gas exchange coefficient, and locomotor activity. A second study investigated the effect of proteins on the regulation of intestinal glucose absorption, on the modulation of the secretion of intestinal hormones and on the inhibition of the DPP-IV (Dipeptidyl peptidase IV) activity and a third study was carried out to determine the effect of proteins on glucose homeostasis. In parallel, complementary functional studies were carried out ex vivo on parts of rat intestine and in vitro on different intestinal cell models. The proteins were then digested using a static gastrointestinal digestion protocol suitable for the digestion of proteins alone. The results obtained globally highlight an effect of the protein source on energy homeostasis via different action on the followed markers. This work also highlights, for the first time, that an acute protein intake could improve glucose tolerance by inhibiting its absorption by the intestine. Indeed, protein digests were able to decrease intestinal glucose absorption in vitro and ex vivo and acute ... |
| نوع الوثيقة: | doctoral or postdoctoral thesis |
| اللغة: | French |
| Relation: | NNT: 2022ULILR028 |
| الاتاحة: | https://hal.science/tel-04550693 https://hal.science/tel-04550693v1/document https://hal.science/tel-04550693v1/file/These_FLEURY_Lea.pdf |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.CF9D0DC8 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |