Academic Journal
Repurposing Study of 4-Acyl-1-phenylaminocarbonyl-2-substituted-piperazine Derivatives as Potential Anticancer Agents—In Vitro Evaluation against Breast Cancer Cells
| العنوان: | Repurposing Study of 4-Acyl-1-phenylaminocarbonyl-2-substituted-piperazine Derivatives as Potential Anticancer Agents—In Vitro Evaluation against Breast Cancer Cells |
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| المؤلفون: | Guillén-Mancina, Emilio, García-Lozano, María del Rosario, Burgos-Morón, Estefanía, Mazzotta, Sarah, Martínez-Aguado, Pablo, Calderón-Montaño, José Manuel, Vega-Pérez, José Manuel, López-Lázaro, Miguel, Iglesias-Guerra, Fernando, Vega-Holm, Margarita |
| المساهمون: | E. Guillén-Mancina, M.D.R. García-Lozano, E. Burgos-Morón, S. Mazzotta, P. Martínez-Aguado, J.M. Calderón-Montaño, J.M. Vega-Pérez, M. López-Lázaro, F. Iglesias-Guerra, M. Vega-Holm |
| بيانات النشر: | MDPI |
| سنة النشر: | 2023 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | aryl urea, breast cancer, cellular viability, piperazine, selective cytotoxic activity, Settore CHIM/06 - Chimica Organica, Settore CHIM/08 - Chimica Farmaceutica |
| الوصف: | Breast cancer is the most common type of cancer in women. Although current treatments can increase patient survival, they are rarely curative when the disease is advanced (metastasis). Therefore, there is an urgent need to develop new cytotoxic drugs with a high selectivity toward cancer cells. Since repurposing approved drugs for cancer therapy has been a successful strategy in recent years, in this study, we screened a library of antiviral piperazine-derived compounds as anticancer agents. The compounds included a piperazine ring and aryl urea functions, which are privileged structures present in several anti-breast cancer drugs. The selective cytotoxic activity of a set of thirty-four 4-acyl-2-substituted piperazine urea derivatives against MCF7 breast cancer cells and MCF 10A normal breast cells was determined. Compounds 31, 32, 35, and 37 showed high selective anticancer activity against breast cancer cells and were also tested against another common type of cancer, non-small cell lung cancer (A549 lung cancer cells versus MRC-5 lung normal cells). Compounds 35 and 37 also showed selectivity against lung cancer cells. These results suggest that compounds 35 and 37 may be promising hit compounds for the development of new anticancer agents. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/38069364; info:eu-repo/semantics/altIdentifier/wos/WOS:001116459900001; volume:24; issue:23; firstpage:1; lastpage:19; numberofpages:19; journal:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; https://hdl.handle.net/2434/1058988; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85179338119 |
| DOI: | 10.3390/ijms242317041 |
| الاتاحة: | https://hdl.handle.net/2434/1058988 https://doi.org/10.3390/ijms242317041 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.CF8DC50D |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms242317041 |
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