Academic Journal
Determination of pentraxin 3 levels in cerebrospinal fluid during central nervous system infections
| العنوان: | Determination of pentraxin 3 levels in cerebrospinal fluid during central nervous system infections |
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| المؤلفون: | Zatta, Marta, Di Bella, Stefano, Bottazzi, Barbara, Rossi, Francesca, D'Agaro, Pierlanfranco, Segat, Ludovica, Fabbiani, Massimiliano, Mantovani, Alberto, Luzzati, Roberto |
| المساهمون: | Zatta, Marta, Di Bella, Stefano, Bottazzi, Barbara, Rossi, Francesca, D'Agaro, Pierlanfranco, Segat, Ludovica, Fabbiani, Massimiliano, Mantovani, Alberto, Luzzati, Roberto |
| سنة النشر: | 2020 |
| المجموعة: | Università degli studi di Trieste: ArTS (Archivio della ricerca di Trieste) |
| مصطلحات موضوعية: | Central nervous system infection, Etiology, Meningiti, Pentraxin3 |
| الوصف: | Pentraxin 3 (PTX3) is an acute phase protein; its plasmatic levels significantly rise during severe infections. Data on PTX3 levels in cerebrospinal fluid (CSF) of patients with central nervous system (CNS) infections are lacking. We aimed (a) to assess the diagnostic potential of measuring CSF PTX3 levels in patients with CNS infections and (b) to establish CSF PTX3 cutoffs to distinguish between bacterial and aseptic meningoencephalitis (ROC curve). PTX3 levels were measured in CSF from 19 patients admitted to Trieste Hospital, Italy, with CNS infection. A diagnosis of bacterial infection and aseptic meningoencephalitis was made in 7 (37%) and 12 (63%) patients, respectively. Subjects with bacterial infections showed significantly higher PTX3 levels (13.5 vs 1.27 ng/mL in aseptic meningoencephalitis, p = 0.010). We identified two different CSF PTX3 levels cutoffs. (1) The best cutoff to maximise Youden's J was 9.6 ng/mL with a sensitivity, specificity, positive predictive value and negative predictive value (NPV) of 71.4%, 91.4%, 83.3%, 84.6%, respectively. (2) The cutoff with higher NPV (100%) was 3.6 ng/mL; a diagnosis of bacterial infections was obtained in 0% patients with CSF PTX3 levels < 3.6 ng/mL vs 58% of those with CSF PTX3 levels ≥ 3.6 ng/mL (p = 0.017). CSF PTX3 levels are higher in bacterial meningitis than aseptic meningoencephalitis. A cutoff of 3.6 ng/mL of CSF PTX3 has a high NPV and can be used to exclude bacterial CNS infections. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/31813079; info:eu-repo/semantics/altIdentifier/wos/WOS:000520706000008; volume:39; issue:4; firstpage:665; lastpage:670; numberofpages:6; journal:EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES; http://hdl.handle.net/11368/2954101; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85076100687; https://link.springer.com/article/10.1007/s10096-019-03767-w |
| DOI: | 10.1007/s10096-019-03767-w |
| الاتاحة: | http://hdl.handle.net/11368/2954101 https://doi.org/10.1007/s10096-019-03767-w https://link.springer.com/article/10.1007/s10096-019-03767-w |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.CF674870 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s10096-019-03767-w |
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