Academic Journal
HIV‐1 impairs in vitro priming of naïve T cells and gives rise to contact‐dependent suppressor T cells
| العنوان: | HIV‐1 impairs in vitro priming of naïve T cells and gives rise to contact‐dependent suppressor T cells |
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| المؤلفون: | Che, Karlhans F., Sabado, Rachel L., Shankar, Esaki M., Tjomsland, Veronica, Messmer, Davorka, Bhardwaj, Nina, Lifson, Jeffrey D., Larsson, Marie |
| المصدر: | European Journal of Immunology ; volume 40, issue 8, page 2248-2258 ; ISSN 0014-2980 1521-4141 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2010 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Priming of T cells in lymphoid tissues of HIV‐infected individuals occurs in the presence of HIV‐1. DC in this milieu activate T cells and disseminate HIV‐1 to newly activated T cells, the outcome of which may have serious implications in the development of optimal antiviral responses. We investigated the effects of HIV‐1 on DC–naïve T‐cell interactions using an allogeneic in vitro system. Our data demonstrate a dramatic decrease in the primary expansion of naïve T cells when cultured with HIV‐1‐exposed DC. CD4 + and CD8 + T cells showed enhanced expression of PD‐1 and TRAIL, whereas CTLA‐4 expression was observed on CD4 + T cells. It is worth noting that T cells primed in the presence of HIV‐1 suppressed priming of other naïve T cells in a contact‐dependent manner. We identified PD‐1, CTLA‐4, and TRAIL pathways as responsible for this suppresion, as blocking these negative molecules restored T‐cell proliferation to a higher degree. In conclusion, the presence of HIV‐1 during DC priming produced cells with inhibitory effects on T‐cell activation and proliferation, i.e. suppressor T cells, a mechanism that could contribute to the enhancement of HIV‐1 pathogenesis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/eji.201040377 |
| الاتاحة: | http://dx.doi.org/10.1002/eji.201040377 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Feji.201040377 https://onlinelibrary.wiley.com/doi/pdf/10.1002/eji.201040377 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.CF2D628B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/eji.201040377 |
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