Academic Journal
Female-dominant estrogen production in healthy children before adrenarche
| العنوان: | Female-dominant estrogen production in healthy children before adrenarche |
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| المؤلفون: | Igarashi, Maki, Ayabe, Tadayuki, Yamamoto-Hanada, Kiwako, Matsubara, Keiko, Sasaki, Hatoko, Saito-Abe, Mayako, Sato, Miori, Mise, Nathan, Ikegami, Akihiko, Shimono, Masayuki, Suga, Reiko, Ohga, Shouichi, Sanefuji, Masafumi, Oda, Masako, Mitsubuchi, Hiroshi, Michikawa, Takehiro, Yamazaki, Shin, Nakayama, Shoji, Ohya, Yukihiro, Fukami, Maki |
| المصدر: | Endocrine Connections ; volume 10, issue 10, page 1221-1226 ; ISSN 2049-3614 |
| بيانات النشر: | Bioscientifica |
| سنة النشر: | 2021 |
| الوصف: | Objective Ultra-sensitive hormone assays have detected slight sex differences in blood estradiol (E 2 ) levels in young children before adrenarche. However, the origin of circulating E 2 in these individuals remains unknown. This study aimed to clarify how E 2 is produced in young girls before adrenarche. Design This is a satellite project of the Japan Environment and Children’s Study organized by the National Institute for Environmental Studies. Methods We collected blood samples from healthy 6-year-old Japanese children (79 boys and 71 girls). Hormone measurements and data analysis were performed in the National Institute for Environmental Studies and the Medical Support Center of the Japan Environment and Children’s Study, respectively. Results E 2 and follicle stimulating hormone (FSH) levels were significantly higher in girls than in boys, while dehydroepiandrosterone sulfate (DHEA-S) and testosterone levels were comparable between the two groups. Girls showed significantly higher E 2 /testosterone ratios than boys. In children of both sexes, a correlation was observed between E 2 and testosterone levels and between testosterone and DHEA-S levels. Moreover, E 2 levels were correlated with FSH levels only in girls. Conclusions The results indicate that in 6-year-old girls, circulating E 2 is produced primarily in the ovary from adrenal steroids through FSH-induced aromatase upregulation. This study provides evidence that female-dominant E 2 production starts several months or years before adrenarche. The biological significance of E 2 biosynthesis in these young children needs to be clarified in future studies. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.1530/ec-21-0134 |
| الاتاحة: | http://dx.doi.org/10.1530/ec-21-0134 https://ec.bioscientifica.com/view/journals/ec/10/10/EC-21-0134.xml https://ec.bioscientifica.com/downloadpdf/journals/ec/10/10/EC-21-0134.xml |
| Rights: | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| رقم الانضمام: | edsbas.CF0FB7C8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1530/ec-21-0134 |
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