Academic Journal
Increased incidence of gap junctional coupling between spinal motoneurones following transient blockade of NMDA receptors in neonatal rats
| العنوان: | Increased incidence of gap junctional coupling between spinal motoneurones following transient blockade of NMDA receptors in neonatal rats |
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| المؤلفون: | Mentis, George Z., Díaz, Eugenia, Moran, Linda B., Navarrete, Roberto |
| المصدر: | The Journal of Physiology ; volume 544, issue 3, page 757-764 ; ISSN 0022-3751 1469-7793 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2002 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Neonatal rat motoneurones are electrically coupled via gap junctions and the incidence of this coupling declines during postnatal development. The mechanisms involved in this developmental regulation of gap junctional communication are largely unknown. Here we have studied the role of NMDA receptor‐mediated glutamatergic synaptic activity in the regulation of motoneurone coupling. Gap junctional coupling was demonstrated by the presence of graded, short latency depolarising potentials following ventral root stimulation, and by the transfer of the low molecular weight tracer Neurobiotin to neighbouring motoneurones. Sites of close apposition between the somata and/or dendrites of the dye‐coupled motoneurones were identified as potential sites of gap junctional coupling. Early postnatal blockade of the NMDA subtype of glutamate receptors using the non‐competitive antagonist dizocilpine maleate (MK801) arrested the developmental decrease in electrotonic and dye coupling during the first postnatal week. These results suggest that the postnatal increase in glutamatergic synaptic activity associated with the onset of locomotion promote the loss of gap junctional connections between developing motoneurones. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1113/jphysiol.2002.028159 |
| الاتاحة: | http://dx.doi.org/10.1113/jphysiol.2002.028159 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1113%2Fjphysiol.2002.028159 https://onlinelibrary.wiley.com/doi/pdf/10.1113/jphysiol.2002.028159 https://onlinelibrary.wiley.com/doi/full-xml/10.1113/jphysiol.2002.028159 https://physoc.onlinelibrary.wiley.com/doi/pdf/10.1113/jphysiol.2002.028159 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.CEC0C03 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1113/jphysiol.2002.028159 |
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