التفاصيل البيبلوغرافية
| العنوان: |
Metabolic Dynamics in Short- and Long-Term Microgravity in Human Primary Macrophages |
| المؤلفون: |
Cora S. Thiel, Christian Vahlensieck, Timothy Bradley, Svantje Tauber, Martin Lehmann, Oliver Ullrich |
| المصدر: |
International Journal of Molecular Sciences; Volume 22; Issue 13; Pages: 6752 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2021 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
spaceflight, sounding rocket, microgravity, metabolomics, immune cells |
| جغرافية الموضوع: |
agris |
| الوصف: |
Microgravity acts on cellular systems on several levels. Cells of the immune system especially react rapidly to changes in gravity. In this study, we performed a correlative metabolomics analysis on short-term and long-term microgravity effects on primary human macrophages. We could detect an increased amino acid concentration after five minutes of altered gravity, that was inverted after 11 days of microgravity. The amino acids that reacted the most to changes in gravity were tightly clustered. The observed effects indicated protein degradation processes in microgravity. Further, glucogenic and ketogenic amino acids were further degraded to Glucose and Ketoleucine. The latter is robustly accumulated in short-term and long-term microgravity but not in hypergravity. We detected highly dynamic and also robust adaptative metabolic changes in altered gravity. Metabolomic studies could contribute significantly to the understanding of gravity-induced integrative effects in human cells. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Molecular Biology; https://dx.doi.org/10.3390/ijms22136752 |
| DOI: |
10.3390/ijms22136752 |
| الاتاحة: |
https://doi.org/10.3390/ijms22136752 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.CEBA58C0 |
| قاعدة البيانات: |
BASE |