Academic Journal
Omega-3 fatty acids and atorvastatin affect connexin 43 expression in the aorta of hereditary hypertriglyceridemic ratsThis article is one of a selection of papers published in a special issue on Advances in Cardiovascular Research.
| العنوان: | Omega-3 fatty acids and atorvastatin affect connexin 43 expression in the aorta of hereditary hypertriglyceridemic ratsThis article is one of a selection of papers published in a special issue on Advances in Cardiovascular Research. |
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| المؤلفون: | Dlugošová, Katarína, Weismann, Peter, Bernátová, Iveta, Sotníková, Ružena, Slezák, Ján, Okruhlicová, Ľudmila |
| المصدر: | Canadian Journal of Physiology and Pharmacology ; volume 87, issue 12, page 1074-1082 ; ISSN 0008-4212 1205-7541 |
| بيانات النشر: | Canadian Science Publishing |
| سنة النشر: | 2009 |
| الوصف: | Statins and omega-3 polyunsaturated fatty acids (n-3 PUFA) reduce cardiovascular disease incidence during hypertriglyceridemia (HTG). To elucidate possible cardioprotective mechanisms, we focused on gap junction protein connexin 43 (Cx43). Its expression is disturbed during atherogenesis, but little information is available on its expression during HTG. Experiments were performed on adult male hereditary HTG (hHTG) rats treated with n-3 PUFA (30 mg/day) and atorvastatin (0.5 mg/100 g body weight per day) for 2 months. Cx43 expression and distribution in the aorta were investigated by using Western blotting and immunolabeling, followed by quantitative analysis. Transmission electronmicroscopy was used to study ultrastructure of endothelial contact sites. In contrast to age-matched Wistar, Cx43 expression in aorta of hHTG rats was significantly higher (p < 0.05), and prominent Cx43 immunospots were seen in tunica media and less in endothelium of hHTG rats. Changes in Cx43 expression were accompanied by local qualitative subcellular alterations of interendothelial connections. Treatment of hHTG rats with n-3 PUFA and atorvastatin markedly lowered Cx43 expression in aorta and modified connexin distribution in endothelium and media (p < 0.05 vs. untreated hHTG). The protective effect of treatment of HTG was observed on the structural integrity of the endothelium and was readily visible at the molecular level. Results indicate the involvement of altered Cx43 expression in vascular pathophysiology during HTG and during HTG treatment. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1139/y09-104 |
| DOI: | 10.1139/Y09-104 |
| الاتاحة: | http://dx.doi.org/10.1139/y09-104 http://www.nrcresearchpress.com/doi/full-xml/10.1139/Y09-104 http://www.nrcresearchpress.com/doi/pdf/10.1139/Y09-104 |
| Rights: | http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMining |
| رقم الانضمام: | edsbas.CE70606A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1139/y09-104 |
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