Academic Journal
De novo Portal Vein Thrombosis in Non-Cirrhotic Non-Alcoholic Fatty Liver Disease: A 9-Year Prospective Cohort Study
| العنوان: | De novo Portal Vein Thrombosis in Non-Cirrhotic Non-Alcoholic Fatty Liver Disease: A 9-Year Prospective Cohort Study |
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| المؤلفون: | Abdel-Razik, Ahmed, Mousa, Nasser, Shabana, Walaa, Yassen, Ahmed H., Abdelsalam, Mostafa, Wahba, Mohamed M., Helmy, Eman Mohamed, Tawfik, Ahmed M., Zalata, Khaled, Hasan, Ahmad S., Elhelaly, Rania, Elzehery, Rasha, Fathy, Aya Ahmed, El-Wakeel, Niveen, Eldars, Waleed |
| المصدر: | Frontiers in Medicine ; volume 8 ; ISSN 2296-858X |
| بيانات النشر: | Frontiers Media SA |
| سنة النشر: | 2021 |
| المجموعة: | Frontiers (Publisher - via CrossRef) |
| الوصف: | Background and Aims: Approximately 30–40% of portal vein thrombosis (PVT) remains of unknown origin. The association between non-alcoholic fatty liver disease (NAFLD) and PVT is a matter of debate. This study aimed to investigate the association between PVT and NAFLD. Methods: We included 94 out of 105 consecutive NAFLD patients in this prospective cohort study in addition to 94 from the healthy control group. We evaluated biochemical, clinical, immunological, and histopathological parameters; waist circumference (WC); leptin; adiponectin; and leptin/adiponectin ratio (LAR) for all participants at baseline and every 3 years thereafter. We described the characteristics of participants at baseline and showed individual WC, LAR, and PVT characteristics. Potential parameters to predict PVT development within 9 years were determined. Results: PVT developed in eight (8.5%) patients, mainly in the portal trunk. Univariate analysis showed three PVT-associated factors: diabetes mellitus ( P = 0.013), WC ( P < 0.001), and LAR ( P = 0.002). After adjusting multiple confounding variables, the multivariate model showed that the only significant variables were WC and LAR. By applying the receiver operating characteristic curve, WC had 98.8% specificity, 87.5% sensitivity, and 0.894 area under the curve (AUC) for prediction of PVT ( P < 0.001) at cutoff values of > 105 cm. In comparison, LAR had 60.5% specificity, 87.5% sensitivity, and 0.805 AUC for PVT prediction ( P < 0.001) at cutoff values of >7.5. Conclusions: This study suggests that increased central obesity and LAR were independently associated with PVT development in non-cirrhotic NAFLD patients, and they should be considered risk factors that may participate in PVT multifactorial pathogenesis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.3389/fmed.2021.650818 |
| DOI: | 10.3389/fmed.2021.650818/full |
| الاتاحة: | http://dx.doi.org/10.3389/fmed.2021.650818 https://www.frontiersin.org/articles/10.3389/fmed.2021.650818/full |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.CE628383 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fmed.2021.650818 |
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