التفاصيل البيبلوغرافية
| العنوان: |
Comparison of oxidative stress parameters in patients with community-acquired pneumonia depending on heart failure severity |
| المؤلفون: |
Cașcaval, V., Fetco-Mereuţă, D., Grib, L.T., Pantea, V.M., Пантя, В.М., Andronache, L.M., Dumitraş, G. |
| المصدر: |
Revista de Ştiinţe ale Sănătăţii din Moldova 29 (3 An.1) 171-171 |
| سنة النشر: |
2022 |
| مصطلحات موضوعية: |
Oxidative stress markers, community-acquired pneumonia, heart failure, Markeri ai stresului oxidativ, pneumonie comunitară, insuficienţă cardiacă |
| الوصف: |
Background. At the present time, the alternation of the oxidative metabolism is considered as one of the leading pathogenic mechanisms in community-acquired pneumonia CAP. However, the direction of the oxidative stress markers changes in patients with CAP and preexistent heart failure HF had been almost unexplored. Objective of the study. To compare the changes of oxidative stress biomarkers levels in patients with CAP depending on HF severity. Materials and Methods. Plasma levels of oxidative stress markers were studied in 77 patients. In study were included 31 men 30.3% and 46 women 59.7%, with the mean age of 68.6 plusmn; 8.01 years. Patients were divided into two groups, according to HF severity: group 1 n = 42 ndash; patients with CAP associated with HF, NYHA stage II, group 2 n = 35 ndash; patients with CAP associated with HF, NYHA stage III. The levels of ischemic modified albumin IMA, advanced glycation end products AGE, catalase, malondialdehyde MDA and superoxide dismutase SOD were compared in both groups. Results. IMA levels were increased in group 2 compared to group 1: 212 plusmn; 54.3 mu;M/L 95% CI 231-99 vs. 189 plusmn; 58.2 mu;M/L 95% CI 171-207, p 0.05. MDA and SOD were without significant changes in both groups. Catalase levels were higher in patients with HF, NYHA stage III: 18.2 plusmn; 6.0 mu;M/L 95% CI 16-20 vs. 15.1 plusmn; 5.3 mu;M/L 95% CI 13-16, p 0.05. AGE products were higher in patients with CAP and advanced HF group 2 compared to group 1: 633 plusmn; 301.4 mu;M/L 95% CI 530-757 vs. 459 plusmn; 181.7 mu;M/L 95% CI 403516, p 0.05. Conclusion. The oxidant/antioxidant imbalance status plays an important role in development and progression of CAP in patients with preexistent HF. ; Introducere. În prezent, alternarea metabolismului oxidativ este considerată ca fiind unul dintre mecanismele patogenice principale în pneumonia comunitară PC. Cu toate acestea, direcția schimbărilor markerilor stresului oxidativ SO la pacienții cu PC și insuficiență cardiacă preexistentă IC a fost aproape ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
23451467 |
| Relation: |
https://ibn.idsi.md/vizualizare_articol/168576; urn:issn:23451467 |
| الاتاحة: |
https://ibn.idsi.md/vizualizare_articol/168576 |
| Rights: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.CE5CFC8C |
| قاعدة البيانات: |
BASE |