Academic Journal
Regulation of mitochondrial activity controls the duration of skeletal muscle regeneration in response to injury
| العنوان: | Regulation of mitochondrial activity controls the duration of skeletal muscle regeneration in response to injury |
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| المؤلفون: | Pessemesse, Laurence, Tintignac, Lionel, Blanchet, Emilie, Cortade, Fabienne, Jublanc, Elodie, Demangel, Rémi, Py, Guillaume, Sar, Chamroeun, Cabello, Gerard, Cabello, Chantal, Casas, François |
| المساهمون: | Dynamique Musculaire et Métabolisme (DMEM), Institut National de la Recherche Agronomique (INRA)-Université de Montpellier (UM), Pharmazentrum, Neuromuscular Res Ctr, Dept Neurol, Dept Biomed, Université de Bâle = University of Basel = Basel Universität (Unibas), Institut National de la Recherche Agronomique (INRA), Institut des Neurosciences de Montpellier (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM) |
| المصدر: | ISSN: 2045-2322. |
| بيانات النشر: | HAL CCSD Nature Publishing Group |
| سنة النشر: | 2019 |
| المجموعة: | Université de Montpellier: HAL |
| مصطلحات موضوعية: | thyroid hormone, t3 receptor, myoblast differentiation, overexpression, proliferation, expression, plays, [SDV]Life Sciences [q-bio] |
| الوصف: | Thyroid hormone is a major regulator of skeletal muscle development and repair, and also a key regulator of mitochondrial activity. We have previously identified a 43 kDa truncated form of the nuclear T3 receptor TR alpha 1 (p43) which stimulates mitochondrial activity and regulates skeletal muscle features. However, its role in skeletal muscle regeneration remains to be addressed. To this end, we performed acute muscle injury induced by cardiotoxin in mouse tibialis in two mouse models where p43 is overexpressed in or depleted from skeletal muscle. The measurement of muscle fiber size distribution at different time point (up to 70 days) upon injury lead us to unravel requirement of the p43 signaling pathway for satellite cells dependent muscle regeneration; strongly delayed in the absence of p43; whereas the overexpression of the receptor enhances of the regeneration process. In addition, we found that satellite cells derived from p43-Tg mice display higher proliferation rates when cultured in vitro when compared to control myoblasts, whereas p43-/- satellites shows reduced proliferation capacity. These finding strongly support that p43 plays an important role in vivo by controling the duration of skeletal muscle regeneration after acute injury, possibly through the regulation of mitochondrial activity and myoblasts proliferation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/31439911; hal-02285621; https://hal.science/hal-02285621; https://hal.science/hal-02285621/document; https://hal.science/hal-02285621/file/2019_Casas_ScientificReports.pdf; PRODINRA: 483518; PUBMED: 31439911; WOS: 000482182200024 |
| DOI: | 10.1038/s41598-019-48703-2 |
| الاتاحة: | https://hal.science/hal-02285621 https://hal.science/hal-02285621/document https://hal.science/hal-02285621/file/2019_Casas_ScientificReports.pdf https://doi.org/10.1038/s41598-019-48703-2 |
| Rights: | http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.CE50FB84 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-019-48703-2 |
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