Academic Journal
Combined effect of Hashimoto's thyroiditis and BRAF V600E mutation status on aggressiveness in papillary thyroid cancer
| العنوان: | Combined effect of Hashimoto's thyroiditis and BRAF V600E mutation status on aggressiveness in papillary thyroid cancer |
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| المؤلفون: | Kim, Su‐jin, Myong, Jun Pyo, Jee, Hyeon‐Gun, Chai, Young Jun, Choi, June Young, Min, Hye Sook, Lee, Kyu Eun, Youn, Yeo‐Kyu |
| المساهمون: | Cancer Research Institute, Seoul National University |
| المصدر: | Head & Neck ; volume 38, issue 1, page 95-101 ; ISSN 1043-3074 1097-0347 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2015 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Background The purpose of this study was to evaluate the association between Hashimoto's thyroiditis and BRAF V600E mutation status in patients with papillary thyroid cancer (PTC) and to determine their combined association with tumor aggressiveness in PTC. Methods A total of 1780 patients with PTC who underwent surgery were enrolled in this study. Simple and multiple analyses were performed to determine the association between Hashimoto's thyroiditis and the BRAF V600E mutation in PTC. Results Hashimoto's thyroiditis was present in 11.5% of patients (204/1780) with PTC. Multiple logistic regressions showed that BRAF V600E (odds ratio [OR] = 0.493; 95% confidence interval [CI] = 0.360–0.678) and the female sex (OR = 7.146; 95% CI = 3.408–18.347) were independent factors associated with Hashimoto's thyroiditis in PTC. BRAF V600E mutation and the Hashimoto's thyroiditis–negative PTC group were associated with aggressive disease (OR = 3.069; 95% CI = 1.654–5.916). Conclusion Hashimoto's thyroiditis was associated less frequently with BRAF V600E , and frequently with the female sex in patients with PTC. Hashimoto's thyroiditis and BRAF V600E status may help to predict clinical outcome of PTC. © 2015 Wiley Periodicals, Inc. Head Neck 38: 95–101, 2016 |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/hed.23854 |
| الاتاحة: | http://dx.doi.org/10.1002/hed.23854 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fhed.23854 https://onlinelibrary.wiley.com/doi/pdf/10.1002/hed.23854 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.CE2A12D4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/hed.23854 |
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