Academic Journal
Multi-System-Level Analysis Reveals Differential Expression of Stress Response-Associated Genes in Inflammatory Solar Lentigo
| العنوان: | Multi-System-Level Analysis Reveals Differential Expression of Stress Response-Associated Genes in Inflammatory Solar Lentigo |
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| المؤلفون: | Jisu Jeong, Wonmin Lee, Ye-Ah Kim, Yun-Ji Lee, Sohyun Kim, Jaeyeon Shin, Yueun Choi, Jihan Kim, Yoonsung Lee, Man S. Kim, Soon-Hyo Kwon |
| المصدر: | International Journal of Molecular Sciences, Vol 25, Iss 7, p 3973 (2024) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2024 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | solar lentigo, RNA-seq data, inflammation, oxidative stress, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Although the pathogenesis of solar lentigo (SL) involves chronic ultraviolet (UV) exposure, cellular senescence, and upregulated melanogenesis, underlying molecular-level mechanisms associated with SL remain unclear. The aim of this study was to investigate the gene regulatory mechanisms intimately linked to inflammation in SL. Skin samples from patients with SL with or without histological inflammatory features were obtained. RNA-seq data from the samples were analyzed via multiple analysis approaches, including exploration of core inflammatory gene alterations, identifying functional pathways at both transcription and protein levels, comparison of inflammatory module (gene clusters) activation levels, and analyzing correlations between modules. These analyses disclosed specific core genes implicated in oxidative stress, especially the upregulation of nuclear factor kappa B in the inflammatory SLs, while genes associated with protective mechanisms, such as SLC6A9, were highly expressed in the non-inflammatory SLs. For inflammatory modules, Extracellular Immunity and Mitochondrial Innate Immunity were exclusively upregulated in the inflammatory SL. Analysis of protein–protein interactions revealed the significance of CXCR3 upregulation in the pathogenesis of inflammatory SL. In conclusion, the upregulation of stress response-associated genes and inflammatory pathways in response to UV-induced oxidative stress implies their involvement in the pathogenesis of inflammatory SL. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/25/7/3973; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067; https://doaj.org/article/0b12fbd2f6874962987ca7f558d3c4d2 |
| DOI: | 10.3390/ijms25073973 |
| الاتاحة: | https://doi.org/10.3390/ijms25073973 https://doaj.org/article/0b12fbd2f6874962987ca7f558d3c4d2 |
| رقم الانضمام: | edsbas.CE0BF8EE |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms25073973 |