Academic Journal
Neurophysiological basis of respiratory discomfort improvement by mandibular advancement in awake OSA patients
| العنوان: | Neurophysiological basis of respiratory discomfort improvement by mandibular advancement in awake OSA patients |
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| المؤلفون: | Valentin, Rémi, Niérat, Marie-Cécile, Wattiez, Nicolas, Jacq, Olivier, Decavèle, Maxens, Arnulf, Isabelle, Similowski, Thomas, Attali, Valérie |
| المساهمون: | Neurophysiologie Respiratoire Expérimentale et Clinique (UMRS 1158), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Institut de Biomécanique Humaine Georges Charpak (IBHGC), Université Sorbonne Paris Nord-Arts et Métiers Sciences et Technologies, HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut Carnot APHP |
| المصدر: | ISSN: 2051-817X ; Physiological Reports ; https://hal.sorbonne-universite.fr/hal-04471365 ; Physiological Reports, 2024, ⟨10.14814/phy2.15951⟩. |
| بيانات النشر: | HAL CCSD Wiley |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | OSA, dyspnea, electroencephalography, neurophysiology, respiratory drive, [SCCO.NEUR]Cognitive science/Neuroscience |
| الوصف: | International audience ; Patients with obstructive sleep apneas (OSA) do not complain from dyspnea during resting breathing. Placement of a mandibular advancement device (MAD) can lead to a sense of improved respiratory comfort ("pseudo-relief") ascribed to a habituation phenomenon. To substantiate this conjecture, we hypothesized that, in non-dyspneic awake OSA patients, respiratory-related electroencephalographic figures, abnormally present during awake resting breathing, would disappear or change in parallel with MAD-associated pseudo-relief. In 20 patients, we compared natural breathing and breathing with MAD on: breathing discomfort (transitional visual analog scale, VAS-2); upper airway mechanics, assessed in terms of pressure peak/time to peak (TTP) ratio respiratory-related electroencephalography (EEG) signatures, including slow event-related preinspiratory potentials; and a between-state discrimination based on continuous connectivity evaluation. MAD improved breathing and upper airway mechanics. The 8 patients in whom the EEG between-state discrimination was considered effective exhibited higher Peak/TTP improvement and transitional VAS ratings while wearing MAD than the 12 patients where it was not. These results support the notion of habituation to abnormal respiratory-related afferents in OSA patients and fuel the causative nature of the relationship between dyspnea, respiratory-related motor cortical activity and impaired upper airway mechanics in this setting. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/38373738; hal-04471365; https://hal.sorbonne-universite.fr/hal-04471365; https://hal.sorbonne-universite.fr/hal-04471365/document; https://hal.sorbonne-universite.fr/hal-04471365/file/Valentin%202024%20Phys%20Rep%20Neurophysiological%20basis%20of%20respiratory%20discomfort%20improvement%20by%20MAD.pdf; PUBMED: 38373738 |
| DOI: | 10.14814/phy2.15951 |
| الاتاحة: | https://hal.sorbonne-universite.fr/hal-04471365 https://hal.sorbonne-universite.fr/hal-04471365/document https://hal.sorbonne-universite.fr/hal-04471365/file/Valentin%202024%20Phys%20Rep%20Neurophysiological%20basis%20of%20respiratory%20discomfort%20improvement%20by%20MAD.pdf https://doi.org/10.14814/phy2.15951 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.CE0395 |
| قاعدة البيانات: | BASE |
| DOI: | 10.14814/phy2.15951 |
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