Academic Journal
Functional marriage in plasma membrane: Critical cholesterol level–optimal protein activity
| العنوان: | Functional marriage in plasma membrane: Critical cholesterol level–optimal protein activity |
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| المؤلفون: | Meza, Ulises, Delgado‐Ramírez, Mayra, Romero‐Méndez, Catalina, Sánchez‐Armass, Sergio, Rodríguez‐Menchaca, Aldo A. |
| المساهمون: | Universidad Autónoma de San Luis Potosí, Consejo Nacional de Ciencia y Tecnología |
| المصدر: | British Journal of Pharmacology ; volume 177, issue 11, page 2456-2465 ; ISSN 0007-1188 1476-5381 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2020 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | In physiology, homeostasis refers to the condition where a system exhibits an optimum functional level. In contrast, any variation from this optimum is considered as a dysfunctional or pathological state. In this review, we address the proposal that a critical cholesterol level in the plasma membrane is required for the proper functioning of transmembrane proteins. Thus, membrane cholesterol depletion or enrichment produces a loss or gain of direct cholesterol–protein interaction and/or changes in the physical properties of the plasma membrane, which affect the basal or optimum activity of transmembrane proteins. Whether or not this functional switching is a generalized mechanism exhibited for all transmembrane proteins, or if it works just for an exclusive group of them, is an open question and an attractive subject to explore at a basic, pharmacological and clinical level. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/bph.15027 |
| الاتاحة: | http://dx.doi.org/10.1111/bph.15027 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fbph.15027 https://onlinelibrary.wiley.com/doi/pdf/10.1111/bph.15027 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/bph.15027 https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/bph.15027 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.CDBE8D53 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/bph.15027 |
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