التفاصيل البيبلوغرافية
| العنوان: |
Effects of a postbiotic and prebiotic mixture on suckling rats' microbiota and immunity |
| المؤلفون: |
Morales Ferré, Carla, Azagra Boronat, Ignasi, Massot Cladera, Malen, Tims, S., Knipping, K., Garssen, J., Knol, J., Franch i Masferrer, Àngels, Castell, Margarida, Rodríguez Lagunas, María José, Pérez-Cano, Francisco J. |
| المصدر: |
Articles publicats en revistes (Bioquímica i Fisiologia) |
| بيانات النشر: |
MDPI |
| سنة النشر: |
2021 |
| المجموعة: |
Dipòsit Digital de la Universitat de Barcelona |
| مصطلحات موضوعية: |
Prebiòtics, Microbiota, Alletament, Rates (Animals de laboratori), Cries d'animals, Prebiotics, Breastfeeding, Rats as laboratory animals, Young animals |
| الوصف: |
Human milk serves as a model for infant formula providing nutritional solutions for infants not able to receive enough mother's milk. Infant formulas aim to mimic the composition and functionality of human milk by providing ingredients reflecting those of the latest human milk insights, such as prebiotics, probiotics and postbiotics. The aim of this study was to examine the effects of the supplementation with a postbiotic (LactofidusTM) and its combination with the prebiotics short-chain galactooligosaccharides (scGOS) and long-chain fructooligosaccharides (lcFOS) in a preclinical model of healthy suckling rats. Pups were supplemented daily with LactofidusTM (POST group) and/or scGOS/lcFOS (P+P and PRE groups, respectively). Body weight and fecal consistency were analyzed. At the end of the study, immunoglobulin (Ig) profile, intestinal gene expression, microbiota composition and short chain fatty acid (SCFA) proportion were quantified. The supplementation with all nutritional interventions modulated the Ig profile, but the prebiotic mixture and the postbiotic induced differential effects: whereas scGOS/lcFOS induced softer feces and modulated microbiota composition and SCFA profile, Lactofidus upregulated Toll-like receptors gene expression. The use of the combination of scGOS/lcFOS and Lactofidus showed the effects observed for the oligosaccharides separately, as well as showing a synergistic impact on animal growth. Thus, the combined use of both products seems to be a good strategy to modulate immune and microbial features in early life. View Full-Text Keywords: postbiotic; prebiotic; suckling rats; Lactofidus; scGOS/lcFOS; microbiota; SCFA |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
2072-6643 |
| Relation: |
Reproducció del document publicat a: https://doi.org/10.3390/nu13092975; Nutrients, 2021, vol. 13, num. 9, p. 2975; https://doi.org/10.3390/nu13092975; http://hdl.handle.net/2445/180459; 714036 |
| الاتاحة: |
http://hdl.handle.net/2445/180459 |
| Rights: |
cc-by (c) Morales Ferré, Carla et al., 2021 ; https://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.CD817B3B |
| قاعدة البيانات: |
BASE |
Full Text Finder