Academic Journal
Hypertension, antihypertensive use and the delayed onset of Huntington's Disease
| العنوان: | Hypertension, antihypertensive use and the delayed onset of Huntington's Disease |
|---|---|
| المؤلفون: | Steventon, Jessica J., Rosser, Anne E., Hart, Emma, Murphy, Kevin |
| بيانات النشر: | Wiley |
| سنة النشر: | 2020 |
| المجموعة: | Cardiff University: ORCA (Online Research @ Cardiff) |
| الوصف: | Background: Hypertension is a modifiable cardiovascular risk factor implicated in neurodegeneration and dementia risk. In Huntington's disease, a monogenic neurodegenerative disease, autonomic and vascular abnormalities have been reported. This study's objective was to examine the relationship between hypertension and disease severity and progression in Huntington's disease. Methods: Using longitudinal data from the largest worldwide observational study of Huntington's disease (n = 14,534), we assessed the relationship between hypertension, disease severity, and rate of clinical progression in Huntington's disease mutation carriers. Propensity score matching was used to statistically match normotensive and hypertensive participants for age, sex, body mass index, ethnicity, and CAG length. Results: Huntington's disease patients had a lower prevalence of hypertension compared with age‐matched gene‐negative controls. Huntington's disease patients with hypertension had worse cognitive function, a higher depression score, and more marked motor progression over time compared with Huntington's disease patients without hypertension. However, hypertensive patients taking antihypertensive medication had less motor, cognitive, and functional impairment than Huntington's disease patients with untreated hypertension and a later age of clinical onset compared with untreated hypertensive patients and normotensive individuals with Huntington's disease. Conclusions: We report the novel finding that hypertension and antihypertensive medication use are associated with altered disease severity, progression, and clinical onset in patients with Huntington's disease. These findings have implications for the management of hypertension in Huntington's disease and suggest that prospective studies of the symptomatic or disease‐modifying potential of antihypertensives in neurodegenerative diseases are warranted. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf; image/tiff |
| اللغة: | English |
| Relation: | https://orca.cardiff.ac.uk/id/eprint/127231/15/mds.27976.pdf; https://orca.cardiff.ac.uk/id/eprint/127231/16/mds27976-sup-0001-supinfo.pdf; https://orca.cardiff.ac.uk/id/eprint/127231/4/fig2_rev%20%28002%29.tiff; https://orca.cardiff.ac.uk/id/eprint/127231/3/fig1_rev%20%28002%29.tiff; Steventon, Jessica J. https://orca.cardiff.ac.uk/view/cardiffauthors/A029932F.html, Rosser, Anne E. https://orca.cardiff.ac.uk/view/cardiffauthors/A043007A.html orcid:0000-0002-4716-4753 orcid:0000-0002-4716-4753, Hart, Emma and Murphy, Kevin https://orca.cardiff.ac.uk/view/cardiffauthors/A132678J.html orcid:0000-0002-6516-313X orcid:0000-0002-6516-313X 2020. Hypertension, antihypertensive use and the delayed onset of Huntington's Disease. Movement Disorders 35 (6) , pp. 937-946. 10.1002/mds.27976 https://doi.org/10.1002/mds.27976 file https://orca.cardiff.ac.uk/id/eprint/127231/15/mds.27976.pdffile https://orca.cardiff.ac.uk/id/eprint/127231/16/mds27976-sup-0001-supinfo.pdffile https://orca.cardiff.ac.uk/id/eprint/127231/4/fig2_rev%20%28002%29.tifffile https://orca.cardiff.ac.uk/id/eprint/127231/3/fig1_rev%20%28002%29.tiff |
| DOI: | 10.1002/mds.27976 |
| الاتاحة: | https://orca.cardiff.ac.uk/id/eprint/127231/ https://doi.org/10.1002/mds.27976 https://orca.cardiff.ac.uk/id/eprint/127231/15/mds.27976.pdf https://orca.cardiff.ac.uk/id/eprint/127231/16/mds27976-sup-0001-supinfo.pdf https://orca.cardiff.ac.uk/id/eprint/127231/4/fig2_rev%20%28002%29.tiff https://orca.cardiff.ac.uk/id/eprint/127231/3/fig1_rev%20%28002%29.tiff |
| Rights: | cc_by |
| رقم الانضمام: | edsbas.CD512C8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/mds.27976 |
|---|