Academic Journal
Heterotopia of salivary gland tissue in the pancreas
| العنوان: | Heterotopia of salivary gland tissue in the pancreas |
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| المؤلفون: | MARTENS, Sandrina, Coolens, Katarina, Olsen, Catharina, Lefesvre, Pierre, Rooman, Ilse |
| المساهمون: | MARTENS, Sandrina, Coolens, Katarina, Olsen, Catharina, Lefesvre, Pierre, Rooman, Ilse |
| بيانات النشر: | BMC |
| سنة النشر: | 2023 |
| المجموعة: | Document Server@UHasselt (Universiteit Hasselt) |
| مصطلحات موضوعية: | Heterotopia, Salivary gland, Submandibular gland, Pancreas, Ectopia |
| الوصف: | Heterotopia of the salivary gland occurs mainly in the head and neck region of the human body, rarely in regions such as the rectum, but has never been demonstrated in the pancreas. Within a screening effort of pancreatic samples for detecting ?Np63 expression, we discovered two pancreatic samples from a 35-year-old male showing salivary gland heterotopia. Immunohistochemical stainings were done for markers of healthy and neoplastic salivary glands and showed expression of calponin, CD142 and KRT14 but not of S100p, GFAP or CD117. A PAS-staining and Alcian Blue staining showed the presence of acid mucins. These staining patterns were consistent with non-neoplastic submandibular gland tissue comprised of abundant seromucous glands, basal cells and myoepithelial cells, all features typically absent in the pancreas. Also, no pancreatic islets of Langerhans were detected. We show for the first time that salivary gland heterotopia can occur at the location of the pancreas. ; Work in the LMMO laboratory was supported by Stichting Tegen Kanker Translational & Clinical Research Grants 2018 #2092 and VUB OZR SRP65. IR is a recipient of an Odysseus I fellowship of the Research Foundation-Flanders (FWO, G0F8916N). KC is a recipient of a PhD Fellowship of the FWO (Grant ID 1157221 N). |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | Diagnostic Pathology, 18 (1) (Art N° 98); http://hdl.handle.net/1942/40879; 18; 001057911300001 |
| DOI: | 10.1186/s13000-023-01385-x |
| الاتاحة: | http://hdl.handle.net/1942/40879 https://doi.org/10.1186/s13000-023-01385-x |
| Rights: | The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.CCFA13D2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s13000-023-01385-x |
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