Academic Journal
Does whole-body bone SPECT/CT provide additional diagnostic information over [18F]-FCH PET/CT for the detection of bone metastases in the setting of prostate cancer biochemical recurrence?
| العنوان: | Does whole-body bone SPECT/CT provide additional diagnostic information over [18F]-FCH PET/CT for the detection of bone metastases in the setting of prostate cancer biochemical recurrence? |
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| المؤلفون: | Nicolas de Leiris, Julien Leenhardt, Bastien Boussat, Christopher Montemagno, Alexandre Seiller, Olivier Phan Sy, Julie Roux, Mathieu Laramas, Camille Verry, Carole Iriart, Gaelle Fiard, Jean-Alexandre Long, Jean-Luc Descotes, Jean-Philippe Vuillez, Laurent Riou, Loïc Djaileb |
| المصدر: | Cancer Imaging, Vol 20, Iss 1, Pp 1-11 (2020) |
| بيانات النشر: | BMC |
| سنة النشر: | 2020 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Bone SPECT/CT, 18F-FCH, PET/CT, Prostate cancer, Biochemical recurrence, Bone metastases, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Background To assess whether whole-body (WB) bone SPECT/CT provides additional diagnostic information over [18F]-FCH PET/CT for the detection of bone metastases in the setting of prostate cancer biochemical recurrence (PC-BR). Methods Patients referred for a PC-BR and whom benefited from a WB bone SPECT/CT and FCH PET/CT were retrospectively included. Tests were classified as positive, equivocal, or negative for bone metastases. A best valuable comparator (BVC) strategy including imaging and follow-up data was used to determine the metastatic status in the absence of systematic histological evaluation. Results Between January 2011 and November 2017, 115 consecutive patients with a PC-BR were evaluated. According to the BVC, 30 patients had bone metastases and 85 patients did not present with bone lesions. The sensitivity, specificity, positive and negative predictive values were respectively 86.7% [69.3–96.2], 98.8% [93.6–100.0], 96.3% [78.7–99.5], and 95.5% [89.4–98.1] for WB bone SPECT/CT and 93.3% [77.9–99.2], 100.0% [95.8–100.0], 100.0 and 97.7% [91.8–99.4] for FCH PET/CT. There was no significant difference in diagnostic accuracy of bone metastases between WB Bone SPECT/CT (AUC 0.824 [0.74–0.90]) and FCH PET/CT (AUC 0.829 [0.75–0.90], p = 0.41). Conclusion Despite good performances for the diagnosis of bone metastases in PC-BR, WB bone SPECT/CT does not provide additive diagnostic information over concomitant FCH PET/CT. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1470-7330 |
| Relation: | http://link.springer.com/article/10.1186/s40644-020-00333-y; https://doaj.org/toc/1470-7330; https://doaj.org/article/3761ac253fc54aca8ee38bae1ce5bee7 |
| DOI: | 10.1186/s40644-020-00333-y |
| الاتاحة: | https://doi.org/10.1186/s40644-020-00333-y https://doaj.org/article/3761ac253fc54aca8ee38bae1ce5bee7 |
| رقم الانضمام: | edsbas.CCE91C94 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14707330 |
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| DOI: | 10.1186/s40644-020-00333-y |