Academic Journal
Activation and regulation of the inflammasomes.
| العنوان: | Activation and regulation of the inflammasomes. |
|---|---|
| المؤلفون: | Latz, Eicke, Xiao, T Sam, Stutz, Andrea |
| المصدر: | Nature reviews / Immunology 13(6), 397-411 (2013). doi:10.1038/nri3452 |
| بيانات النشر: | Nature Publ. Group |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | info:eu-repo/classification/ddc/570, Autophagy: immunology, Carrier Proteins: immunology, Carrier Proteins: metabolism, Humans, Inflammasomes: immunology, Inflammasomes: metabolism, Inflammation Mediators: immunology, Inflammation Mediators: metabolism, Interleukin-18: immunology, Interleukin-18: metabolism, Interleukin-1beta: immunology, Interleukin-1beta: metabolism, Models, Immunological, NLR Family, Pyrin Domain-Containing 3 Protein, Receptors, Interleukin-1: immunology, Interleukin-1: metabolism, Signal Transduction: immunology, Carrier Proteins, Inflammasomes, Inflammation Mediators, Interleukin-18, Interleukin-1beta, NLRP3 protein, human, Interleukin-1 |
| جغرافية الموضوع: | DE |
| الوصف: | Inflammasomes are key signalling platforms that detect pathogenic microorganisms and sterile stressors, and that activate the highly pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18. In this Review, we discuss the complex regulatory mechanisms that facilitate a balanced but effective inflammasome-mediated immune response, and we highlight the similarities to another molecular signalling platform - the apoptosome - that monitors cellular health. Extracellular regulatory mechanisms are discussed, as well as the intracellular control of inflammasome assembly, for example, via ion fluxes, free radicals and autophagy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/issn/1474-1741; info:eu-repo/semantics/altIdentifier/issn/1474-1733; info:eu-repo/semantics/altIdentifier/pmid/pmid:23702978; https://pub.dzne.de/record/136923; https://pub.dzne.de/search?p=id:%22DZNE-2020-03245%22 |
| الاتاحة: | https://pub.dzne.de/record/136923 https://pub.dzne.de/search?p=id:%22DZNE-2020-03245%22 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.CCE524C9 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |