Academic Journal
Socio-demographic and drug use factors associated with HIV-1 recombinants and dual infections in Northern Thai drug users: Associations of risk with genetic complexity
| العنوان: | Socio-demographic and drug use factors associated with HIV-1 recombinants and dual infections in Northern Thai drug users: Associations of risk with genetic complexity |
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| المؤلفون: | Kijak, G. H., Beyrer, C., Tovanabutra, S., Sripaipan, T., Suriyanon, V., Moqueet, N., Sanders-Buell, E., Saokhieo, P., Timpan, U., Jittiwutikarn, J., Robb, M. L., Birx, D. L., Celentano, D. D., McCutchan, F. E. |
| المصدر: | US Army Research |
| بيانات النشر: | DigitalCommons@University of Nebraska - Lincoln |
| سنة النشر: | 2010 |
| المجموعة: | University of Nebraska-Lincoln: DigitalCommons@UNL |
| مصطلحات موضوعية: | Injection drug use, HIV/AIDS, Recombination, Dual infection, Molecular epidemiology, Injecting risk, Thailand, Multi-region hybridization assay, Operations Research, Systems Engineering and Industrial Engineering |
| الوصف: | Background: Dual infection with diverse HIV strains can foster the emergence of recombinants. The resulting increase in viral genetic diversity is a major challenge for vaccine development HIV treatment. In this study we aim to investigate the socio demographic factors associated with an increasing level of genetic diversity among HIV strains in a population of drug-users in Northern Thailand. Methods: From 1999 through 2000, 2231 volunteers were enrolled in the Opiate- Users Research in Chiang Mai, Thailand. HIV subtype analysis was conducted among those HIV-1 seropositive (n = 347) using a multi-region hybridization assay. Social and demographic variables were assessed using a structured questionnaire. Results: Overall, 336/347 (96.8%) of the samples could be typed. 81.8% were CRF01_AE, 3.9% were sub-type B, 9.2% were recombinants (mostly between CRF01_AE and B) and 5.1% were dual infections. Dual infections were more frequent among those with a lower education level (AOR:5.2; 95% Cl 1.4–20.3), those who have initiated injecting in the last 3 years (AOR:3.9; 95% Cl 1.1–14.6), and those reporting frequent needle sharing in the last 3 months (AOR:7.0; 95% Cl 1.5–34.1). Both recombinant strains and dual infection were more frequent among those reporting frequent needle sharing in the last 3months (AOR: 5.3; 95% Cl 1.6–17.1). Conclusion: To limit the expanding complexity of HIV-1 strains, early intervention should be aimed at reduction in needle sharing, especially among new intravenous drug users. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| Relation: | https://digitalcommons.unl.edu/usarmyresearch/133; https://digitalcommons.unl.edu/context/usarmyresearch/article/1132/viewcontent/Kijak_DAD_2010_Sociodemographic_drug_use.pdf |
| الاتاحة: | https://digitalcommons.unl.edu/usarmyresearch/133 https://digitalcommons.unl.edu/context/usarmyresearch/article/1132/viewcontent/Kijak_DAD_2010_Sociodemographic_drug_use.pdf |
| رقم الانضمام: | edsbas.CCE242B4 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |