Academic Journal
Type I Interferons Suppress Anti-parasitic Immunity and Can Be Targeted to Improve Treatment of Visceral Leishmaniasis
| العنوان: | Type I Interferons Suppress Anti-parasitic Immunity and Can Be Targeted to Improve Treatment of Visceral Leishmaniasis |
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| المؤلفون: | Kumar, Rajiv, Bunn, Patrick T, Singh, Siddharth Sankar, Ng, Susanna S, de Oca, Marcela Montes, Rivera, Fabian De labastida, Chauhan, Shashi Bhushan, Singh, Neetu, Faleiro, Rebecca J, Edwards, Chelsea L, Frame, Teija CM, Sheel, Meru, Austin, Rebecca J, Engwerda, Christian R |
| بيانات النشر: | Cell Press |
| سنة النشر: | 2020 |
| المجموعة: | Griffith University: Griffith Research Online |
| مصطلحات موضوعية: | Biochemistry and cell biology, Medical physiology, Science & Technology, Life Sciences & Biomedicine, T-CELL, DENDRITIC CELLS |
| الوصف: | Type I interferons (IFNs) play critical roles in anti-viral and anti-tumor immunity. However, they also suppress protective immune responses in some infectious diseases. Here, we identify type I IFNs as major upstream regulators of CD4+ T cells from visceral leishmaniasis (VL) patients. Furthermore, we report that mice deficient in type I IFN signaling have significantly improved control of Leishmania donovani, a causative agent of human VL, associated with enhanced IFNγ but reduced IL-10 production by parasite-specific CD4+ T cells. Importantly, we identify a small-molecule inhibitor that can be used to block type I IFN signaling during established infection and acts synergistically with conventional anti-parasitic drugs to improve parasite clearance and enhance anti-parasitic CD4+ T cell responses in mice and humans. Thus, manipulation of type I IFN signaling is a promising strategy for improving disease outcome in VL patients. ; Full Text |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2211-1247 |
| Relation: | Cell Reports; Kumar, R; Bunn, PT; Singh, SS; Ng, SS; de Oca, MM; Rivera, FDL; Chauhan, SB; Singh, N; Faleiro, RJ; Edwards, CL; Frame, TCM; Sheel, M; Austin, RJ; Engwerda, CR, et al., Type I Interferons Suppress Anti-parasitic Immunity and Can Be Targeted to Improve Treatment of Visceral Leishmaniasis, Cell Reports, 2020, 30 (8), pp. 2512; http://hdl.handle.net/10072/396118 |
| DOI: | 10.1016/j.celrep.2020.01.099 |
| الاتاحة: | http://hdl.handle.net/10072/396118 https://doi.org/10.1016/j.celrep.2020.01.099 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ ; © 2020 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ; open access |
| رقم الانضمام: | edsbas.CCCB776B |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 22111247 |
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| DOI: | 10.1016/j.celrep.2020.01.099 |