Academic Journal
Structural Catalytic Core in Subtilisin-like Proteins and Its Comparison to Trypsin-like Serine Proteases and Alpha/Beta-Hydrolases
| العنوان: | Structural Catalytic Core in Subtilisin-like Proteins and Its Comparison to Trypsin-like Serine Proteases and Alpha/Beta-Hydrolases |
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| المؤلفون: | Denesyuk, Alexandre, Denessiouk, Konstantin, Johnson, Mark, Uversky, Vladimir |
| المصدر: | Denesyuk , A , Denessiouk , K , Johnson , M & Uversky , V 2024 , ' Structural Catalytic Core in Subtilisin-like Proteins and Its Comparison to Trypsin-like Serine Proteases and Alpha/Beta-Hydrolases ' , International Journal of Molecular Sciences , vol. 25 , no. 22 , 11858 , pp. 11858 . https://doi.org/10.3390/ijms252211858 |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | alpha/beta-hydrolases, catalytic pentad, serine proteases, subtilisin-like |
| الوصف: | Subtilisin-like proteins are serine proteases that use two types of catalytic triads: Ser-His-Asp and Ser-Glu-Asp. Here, we investigate the two known families of subtilisin-like proteins, the subtilases (Ser-His-Asp triad) and the serine-carboxyl proteinases (Ser-Glu-Asp triad), and describe the local structural arrangements (cores) that govern the catalytic residues in these proteins. We show the separation of the cores into conserved structural zones, which can be repeatedly found in different structures, and compare the structural cores in subtilisin-like proteins with those in trypsin-like serine proteases and alpha/beta-hydrolases. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.3390/ijms252211858 |
| الاتاحة: | https://research.abo.fi/en/publications/8e9de6a5-0c49-4fee-ade4-f47d6a47d0df https://doi.org/10.3390/ijms252211858 https://research.abo.fi/ws/files/64894850/ijms-25-11858.pdf https://urn.fi/URN:NBN:fi-fe20241213102315 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.CCAC9219 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms252211858 |
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