التفاصيل البيبلوغرافية
| العنوان: |
Chemical Factors Important to Calcium Nephrolithiasis - Evidence for Impaired Hydroxycarboxylic Acid Absorption Causing Hyperoxaluria |
| المؤلفون: |
Cowley, DM, McWhinney, BC, Brown, JM, Chalmers, AH |
| بيانات النشر: |
AMER ASSOC CLINICAL CHEMISTRY |
| سنة النشر: |
1987 |
| المجموعة: |
The University of Queensland: UQ eSpace |
| مصطلحات موضوعية: |
Medical Laboratory Technology, 1308 Clinical Biochemistry, 2704 Biochemistry, medical |
| الوصف: |
An investigation of variables important to calcium stone formation in urine indicated significantly increased daily excretion of calcium and oxalate and decreased excretion of ascorbate and citrate by recurrent calcium stone formers. In addition, urine volume, sodium, mucopolysaccharide, and protein were also significantly increased. We compared the uptake of citrate and ascorbate from the gut into the blood in normal controls and stone formers. These studies indicated significantly depressed absorption of both these hydroxycarboxylic acids in recurrent calcium stone formers. We also found that concurrent administration of citrate inhibited ascorbate absorption and increased urinary oxalate excretion after an ascorbate load in normal subjects and stone formers. These findings suggest a mechanism that explains hyperoxaluria in stone patients on the basis of a malabsorption of citrate, ascorbate, and possibly other hydroxycarboxylic acids. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| تدمد: |
0009-9147 |
| Relation: |
orcid:0000-0002-4153-934X |
| الاتاحة: |
https://espace.library.uq.edu.au/view/UQ:328766 |
| رقم الانضمام: |
edsbas.CC753217 |
| قاعدة البيانات: |
BASE |