Academic Journal
IL‐1β‐dependent activation of NF‐κB mediates PGE 2 release via the expression of cyclooxygenase‐2 and microsomal prostaglandin E synthase
| العنوان: | IL‐1β‐dependent activation of NF‐κB mediates PGE 2 release via the expression of cyclooxygenase‐2 and microsomal prostaglandin E synthase |
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| المؤلفون: | Catley, Matthew C., Chivers, Joanna E., Cambridge, Lisa M., Holden, Neil, Slater, Donna M., Staples, Karl J., Bergmann, Martin W., Loser, Peter, Barnes, Peter J., Newton, Robert |
| المصدر: | FEBS Letters ; volume 547, issue 1-3, page 75-79 ; ISSN 0014-5793 1873-3468 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2003 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Prostaglandin (PG) E 2 release is induced in pulmonary A549 cells by the NF‐κB‐activating stimuli interleukin‐1β (IL‐1β) and phorbol 12‐myristate 13‐acetate (PMA). Adenoviral over‐expression of IκBαΔN, a dominant NF‐κB inhibitor, prevents NF‐κB‐dependent transcription and was used to qualify the role of NF‐κB in the release of PGE 2 . IκBαΔN repressed IL‐1β‐induced, but not PMA‐induced, cycloxygenase‐2 (COX‐2) and microsomal prostaglandin E synthase (mPGES) expression. These data conclusively demonstrate a substantial role for NF‐κB in the co‐ordinate induction of COX‐2, mPGES and in the corresponding release of PGE 2 by IL‐1β. However, other pathways are primarily responsible for PGE 2 release induced by PMA. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1016/s0014-5793(03)00672-0 |
| DOI: | 10.1016/S0014-5793%2803%2900672-0 |
| الاتاحة: | http://dx.doi.org/10.1016/s0014-5793(03)00672-0 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2FS0014-5793%2803%2900672-0 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2FS0014-5793(03)00672-0 https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/S0014-5793%2803%2900672-0 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.CC6F0ACE |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/s0014-5793(03)00672-0 |
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