Academic Journal
Evaluation of APRI and FIB-4 scoring systems for non-invasive assessment of hepatic fibrosis in chronic hepatitis B patients
| العنوان: | Evaluation of APRI and FIB-4 scoring systems for non-invasive assessment of hepatic fibrosis in chronic hepatitis B patients |
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| المؤلفون: | Kim, W R, Berg, Thomas, Asselah, Tarik, Flisiak, Robert, Fung, Scott, Gordon, Stuart C, Janssen, Harry LA, Lampertico, Pietro, Lau, Daryl, Bornstein, Jeffrey D, Schall, Raul EA, Dinh, Phillip, Yee, Leland J, Martins, Eduardo B, Lim, Seng-Gee, Loomba, Rohit, Petersen, Jörg, Buti, Maria, Marcellin, Patrick |
| المصدر: | Gastroenterology Articles |
| بيانات النشر: | Henry Ford Health Scholarly Commons |
| سنة النشر: | 2016 |
| المجموعة: | Henry Ford Health System Scholarly Commons |
| مصطلحات موضوعية: | Adult, Aspartate Aminotransferases, Biopsy, Female, Hepatitis B, Chronic, Humans, Liver, Liver Cirrhosis, Male, Platelet Count, Severity of Illness Index |
| الوصف: | BACKGROUND & AIMS: While the gold standard in the assessment of liver fibrosis remains liver biopsy, non-invasive methods have been increasingly used for chronic hepatitis B (CHB). This study aimed to evaluate the performance of two commonly used non-invasive scoring systems (aspartate aminotransferase-to-platelet ratio index (APRI) and fibrosis index based on four factors (FIB-4)) to predict fibrosis stage in CHB patients. METHODS: Demographic, histologic and clinical laboratory data from two trials investigating tenofovir disoproxil fumarate in CHB were analyzed. Predicted fibrosis stage, based on established scales and cut-off values for APRI and FIB-4 scores, was compared with Ishak scores obtained from liver biopsy at baseline and at 240 week follow-up. RESULTS: In the 575 patients with a baseline liver biopsy, APRI and FIB-4 scores correlated with Ishak stage (p CONCLUSIONS: APRI and FIB-4 scores are not suitable for use in clinical practice in CHB patients for assessment of hepatic fibrosis according to Ishak stage, especially in gauging improvements in liver fibrosis following therapy. |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| Relation: | https://scholarlycommons.henryford.com/gastroenterology_articles/144; http://sfxhosted.exlibrisgroup.com/hfhs?sid=Entrez:PubMed&id=pmid:26626497 |
| الاتاحة: | https://scholarlycommons.henryford.com/gastroenterology_articles/144 http://sfxhosted.exlibrisgroup.com/hfhs?sid=Entrez:PubMed&id=pmid:26626497 |
| رقم الانضمام: | edsbas.CC5DF299 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |