Academic Journal
Identification of p60 antibodies in human sera and presentation of this listerial antigen on the surface of attenuated salmonellae by the HlyB-HlyD secretion system
| العنوان: | Identification of p60 antibodies in human sera and presentation of this listerial antigen on the surface of attenuated salmonellae by the HlyB-HlyD secretion system |
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| المؤلفون: | Gentschev, I, Sokolovic, Z, Köhler, S, Krohne, G F, Hof, H, Wagner, J, Goebel, W |
| المصدر: | Infection and Immunity ; volume 60, issue 12, page 5091-5098 ; ISSN 0019-9567 1098-5522 |
| بيانات النشر: | American Society for Microbiology |
| سنة النشر: | 1992 |
| الوصف: | Antibodies directed against the major secreted protein of Listeria monocytogenes, termed p60, were found more frequently than antilisteriolysin antibodies in sera of listeriosis patients. Anti-p60 antibodies were also identified in all tested sera from healthy individuals. To test whether p60 provides protection against L. monocytogenes, we constructed an attenuated Salmonella typhimurium aroA strain which secretes p60 via the Escherichia coli hemolysin secretion pathway. Application of this Salmonella strain to BALB/c mice prior to an L. monocytogenes infection induced p60 antibodies in these mice and led to a significantly reduced number of viable bacteria in the spleen compared with that in control animals which were primed with the S. typhimurium aroA strain alone. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1128/iai.60.12.5091-5098.1992 |
| الاتاحة: | http://dx.doi.org/10.1128/iai.60.12.5091-5098.1992 https://journals.asm.org/doi/pdf/10.1128/iai.60.12.5091-5098.1992 |
| Rights: | https://journals.asm.org/non-commercial-tdm-license |
| رقم الانضمام: | edsbas.CC3D6091 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1128/iai.60.12.5091-5098.1992 |
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