Academic Journal
Value of systolic pulmonary arterial pressure as a prognostic factor of death in the systemic sclerosis EUSTAR population
| العنوان: | Value of systolic pulmonary arterial pressure as a prognostic factor of death in the systemic sclerosis EUSTAR population |
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| المؤلفون: | E. Hachulla, P. Clerson, P. Airò, G. Cuomo, Y. Allanore, P. Caramaschi, E. Rosato, P. E. Carreira, V. Riccieri, M. Sarraco, C. P. Denton, G. Riemekasten, M. R. Pozzi, S. Zeni, C. M. Mihai, S. Ullman, O. Distler, S. Rednic, V. Smith, U. A. Walker, M. Matucci Cerinic, U. Müller Ladner, D. Launay, EUSTAR co workersPierre Yves Hatron, Sandrine Morell Dubois, Hélène Maillard, Amandine Verhaghe, Géraldine Wojtasik, Camille Bourdon, Sarahe Dehimat, Aurélie Noullez, Marie Fertin, Pascal de Groote, Nicolas Lamblin, Lille, France, Jörg Distler, Helena Reichter, Erlangen, Germany, Raffaele Pellerito, Torino, Italy, Pia Moinzadeh, London, UK, Vincent Sobanski, Milano, Italy, Serena Guiducci, Silvia Bellando Randone, Florence, Italy, Suzana Jordan, Zurich, Switzerland, Lidia Ananieva, Moscow, Russia, Alan Tyndall, Basel, Switzerland, F. Meier andM Frerix, Bad Nauheim, Germany, Alexandra Balbir Gurman, Haïfa, Israel, Rosario Foti, Catania Italy, Radim Becvar, Praha, Czech Republic, Gabriella Szucs, Debrecen, Hungary, Maurizio Cutolo, Genova, Italy, Mohammed Tikly, Johannesburg, South Africa, Bianca Marasini, Laura Belloli Rozzano, Maria João Salvador, Coimbra, Portugal, Agneta Scheja, Roger, Hesselstarnd, Lund, Sweden, Panayiotis G. Vlachoyiannopoulos, Lily Bournia, Athens, Greece, Armando Gabrielli, Paolo Fraticelli, Ancona, Italy, Vera Ortiz Santamaria, Granollers Barcelona, Spain, Malgorzata Michalska Jakubus, Lublin, Poland, Luc Mouthon, Alice Berezné, Paris, France, Ruxandra Ionescu, Bucharest, Romania, Martin Aringer, Dresden, Germany, Thierry Zenone, Valence, France, Kamal Solanki, Hamilton, New Zealand, Simon Stebbings, Dunedin, New Zetland, Lisa Stamp, Christchurch, Tanaseanu Cristina, Codrina Ancuta, Iasi, Romania, Paloma García de la Peña Lefebvre, Madrid, Spain, Emmanuel Chatelus, Strasbourg, France, Matthias Seidel, Bonn, Germany, Agachi Svetlana, Chisinau, Republic of Moldova, Franco Cozzi, Padova, Italy, Francesca Ingegnoli |
| المساهمون: | E. Hachulla, P. Clerson, P. Airò, G. Cuomo, Y. Allanore, P. Caramaschi, E. Rosato, P.E. Carreira, V. Riccieri, M. Sarraco, C.P. Denton, G. Riemekasten, M.R. Pozzi, S. Zeni, C.M. Mihai, S. Ullman, O. Distler, S. Rednic, V. Smith, U.A. Walker, M. Matucci Cerinic, U. Müller Ladner, D. Launay, E. co workersPierre Yves Hatron, S. Morell Duboi, H. Maillard, A. Verhaghe, G. Wojtasik, C. Bourdon, S. Dehimat, A. Noullez, M. Fertin, P. de Groote, N. Lamblin, L. France, J. Distler, H. Reichter, E. Germany, R. Pellerito, T. Italy, P. Moinzadeh, L. Uk, V. Sobanski, F.A. Ingegnoli, M. Italy, S. Guiducci, S. Bellando Randone, F. Italy, S. Jordan, Z. Switzerland, L. Ananieva, M. Russia, A. Tyndall, B. Switzerland, F. Meier andM Frerix, B. Nauheim, Germany, A. Balbir Gurman, H. Israel, R. Foti, C. Italy, R. Becvar, Praha, C. Republic, G. Szuc, D. Hungary, M. Cutolo, G. Italy, M. Tikly, Johannesburg, S. Africa, B. Marasini, L. Belloli Rozzano, M. João Salvador, C. Portugal, A. Scheja, R. Hesselstarnd, L. Sweden, P.G. Vlachoyiannopoulo, L. Bournia, A. Greece, A. Gabrielli, P. Fraticelli, A. Italy, V. Ortiz Santamaria, G. Barcelona, Spain, M. Michalska Jakubu, L. Poland, L. Mouthon, A. Berezné, P. France, R. Ionescu, B. Romania, M. Aringer, D. Germany, T. Zenone, V. France |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2015 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | Pulmonary hypertension, Survival, Systemic sclerosi, Systolic pulmonary arterial pressure, Tricuspid regurgitant jet velocity, Adult, Aged, Blood Pressure, Cohort Studie, Echocardiography, Europe, Female, Follow-Up Studie, Human, Hypertension, Pulmonary, Male, Middle Aged, Multivariate Analysi, Prognosi, Pulmonary Artery, Retrospective Studie, Risk Factor, Scleroderma, Systemic, Survival Rate, Systole, Rheumatology, Pharmacology (medical), Settore MED/16 - Reumatologia |
| الوصف: | Objective. The aim of this study was to assess the prognostic value of systolic pulmonary artery pressure (sPAP) estimated by echocardiography in the multinational European League Against Rheumatism Scleroderma Trial and Research (EUSTAR) cohort.Methods. Data for patients with echocardiography documented between 1 January 2005 and 31 December 2011 were extracted from the EUSTAR database. Stepwise forward multivariable statistical Cox pulmonary hypertension analysis was used to examine the independent effect on survival of selected variables.Results. Based on our selection criteria, 1476 patients were included in the analysis; 87% of patients were female, with a mean age of 56.3 years (s.d. 13.5) and 31% had diffuse SSc. The mean duration of follow-up was 2.0 years (s.d. 1.2, median 1.9). Taking index sPAP of <30 mmHg as reference, the hazard ratio (HR) for death was 1.67 (95% CI 0.92, 2.96) if the index sPAP was between 30 and 36 mmHg, 2.37 (95% CI 1.14, 4.93) for sPAP between 36 and 40 mmHg, 3.72 (95% CI 1.61, 8.60) for sPAP between 40 and 50 mmHg and 9.75 (95% CI 4.98, 19.09) if sPAP was >50 mmHg. In a multivariable Cox model, sPAP and the diffusing capacity for carbon monoxide (DLCO) were independently associated with the risk of death [HR 1.833 (95% CI 1.035, 3.247) and HR 0.973 (95% CI 0.955, 0.991), respectively]. sPAP was an independent risk factor for death with a HR of 3.02 (95% CI 1.91, 4.78) for sPAP ≥36 mmHg.Conclusion. An estimated sPAP >36 mmHg at baseline echocardiography was significantly and independently associated with reduced survival, regardless of the presence of pulmonary hypertension based on right heart catheterization. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/25596413; info:eu-repo/semantics/altIdentifier/wos/WOS:000357430500021; volume:54; issue:7; firstpage:1262; lastpage:1269; numberofpages:8; journal:RHEUMATOLOGY; http://hdl.handle.net/2434/344038; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84936862994 |
| DOI: | 10.1093/rheumatology/keu450 |
| الاتاحة: | http://hdl.handle.net/2434/344038 https://doi.org/10.1093/rheumatology/keu450 |
| رقم الانضمام: | edsbas.CC323DB4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/rheumatology/keu450 |
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