Academic Journal
Persistence of minimal residual disease in bone marrow predicts outcome in follicular lymphomas treated with a rituximab-intensive program
| العنوان: | Persistence of minimal residual disease in bone marrow predicts outcome in follicular lymphomas treated with a rituximab-intensive program |
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| المؤلفون: | LADETTO, Marco, Lobetti Bodoni C, MANTOAN, BARBARA, Ceccarelli M, Boccomini C, GENUARDI, ELISA, Chiappella A, Baldini L, Rossi G, Pulsoni A, Di Raimondo F, Rigacci L, Pinto A, Galimberti S, Bari A, Rota Scalabrini D, Ferrari A, Zaja F, Gallamini A, Specchia G, Musto P, Rossi FG, Gamba E, Evangelista A, Vitolo U, Fondazione Italiana L.i.n.f.o.m.i. collaborators: Lobetti Bodoni C, Mantoan B, Genuardi E, Boccadoro M, Ladetto M, Ciccone G, Botto B, Orsucci L, Goldaniga M, Bottelli C, Tucci A, De Angelis F, Russo E, Martelli M, Foà R, Chiarenza A, Puccini B, Bosi A, Petrini M, Sacchi S, Federico M, AGLIETTA, Massimo, Alvarez De Celis I, Merli F, Fanin R, Castellino C, Parvis G, SAGLIO, Giuseppe, Perrone T, Corradini P, Pogliani EM, Liberati AM, Leone G, Patti C, Fioritoni G, Rusconi C, Morra E, Tonso A, Cabras G, Angelucci E, Rossi A, Rambaldi A, Cortelazzo S, Morandi S, Lanza F, Pizzolo G, Amadori S, Zinzani PL, Stelitano C, Nobile F. |
| المساهمون: | Ladetto M, Lobetti-Bodoni C, Mantoan B, Ceccarelli M, Boccomini C, Genuardi E, Chiappella A, Baldini L, Rossi G, Pulsoni A, Di Raimondo F, Rigacci L, Pinto A, Galimberti S, Bari A, Rota-Scalabrini D, Ferrari A, Zaja F, Gallamini A, Specchia G, Musto P, Rossi FG, Gamba E, Evangelista A, Vitolo U, Fondazione Italiana Linfomi. collaborators: Lobetti-Bodoni C, Boccadoro M, Ciccone G, Botto B, Orsucci L, Goldaniga M, Bottelli C, Tucci A, De Angelis F, Russo E, Martelli M, Foà R, Chiarenza A, Puccini B, Bosi A, Petrini M, Sacchi S, Federico M, Aglietta M, Alvarez De Celis I, Merli F, Fanin R, Castellino C, Parvis G, Saglio G, Perrone T, Corradini P, Pogliani EM, Liberati AM, Leone G, Patti C, Fioritoni G, Rusconi C, Morra E, Tonso A, Cabras G, Angelucci E, Rossi A, Rambaldi A, Cortelazzo S, Morandi S, Lanza F, Pizzolo G, Amadori S, Zinzani PL, Stelitano C, Nobile F |
| سنة النشر: | 2013 |
| المجموعة: | Università degli studi di Torino: AperTo (Archivio Istituzionale ad Accesso Aperto) |
| مصطلحات موضوعية: | minimal resdual disease, bone marrow, follicular lymphomas |
| الوصف: | We assessed the prognostic value of minimal residual disease (MRD) within the ML17638 phase 3 trial from the Fondazione Italiana Linfomi, investigating the role of rituximab maintenance in elderly follicular lymphoma (FL) patients after a brief first-line chemoimmunotherapy. MRD for the bcl-2/IgH translocation was determined on bone marrow cells in a centralized laboratory belonging to the Euro-MRD consortium, using qualitative and quantitative polymerase chain reactions (PCRs). Of 234 enrolled patients, 227 (97%) were screened at diagnosis. A molecular marker (MM) was found in 51%. Patients with an MM were monitored at 8 subsequent times. Of the 675 expected follow-up samples, 83% were analyzed. Conversion to PCR negativity predicted better progression-free survival (PFS) at all post-treatment times (eg, end of therapy: 3-year PFS, 72% vs 39%; P < .007). MRD was predictive in both maintenance (83% vs 60%; P < .007) and observation (71% vs 50%; P < .001) groups. PCR positivity at the end of induction was an independent adverse predictor (hazard ratio, 3.1; 95% confidence interval, 1.36-7.07). MRD is a powerful independent outcome predictor in FL patients who receive rituximab-intensive programs, suggesting a need to investigate its value for decision-making. This trial was registered at www.clinicaltrial.gov as #NCT01144364. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/24085766; info:eu-repo/semantics/altIdentifier/wos/WOS:000329735000014; volume:122; issue:23; firstpage:3759; lastpage:3766; numberofpages:8; journal:BLOOD; http://hdl.handle.net/2318/157628; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84891043722; http://bloodjournal.hematologylibrary.org/content/122/23/3759.long |
| DOI: | 10.1182/blood-2013-06-507319 |
| الاتاحة: | http://hdl.handle.net/2318/157628 https://doi.org/10.1182/blood-2013-06-507319 http://bloodjournal.hematologylibrary.org/content/122/23/3759.long |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.CC1B2505 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1182/blood-2013-06-507319 |
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