Academic Journal
Nucleotide incorporation against 7,8-dihydro-8-oxoguanine is influenced by neighboring base sequences in TLS DNA polymerase reaction
| العنوان: | Nucleotide incorporation against 7,8-dihydro-8-oxoguanine is influenced by neighboring base sequences in TLS DNA polymerase reaction |
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| المؤلفون: | Yung, ChinWei, Suzuki, Tetsuya, Okugawa, Yoji, Kawakami, Asako, Loakes, David, Negishi, Kazuo, Negishi, Tomoe |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2007 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Articles |
| الوصف: | 7,8-Dihydro-8-oxoguanine (8-oxoG) is a well-known oxidative lesion in DNA and is related to carcinogenesis and ageing processes. Misincorporation of dATP opposite to 8-oxoG leads to G → T transversion mutations. DNA sequence has been proved as an important factor influencing the replication and enzymatic repair of various types of damages. To explore the influence of sequence effect on the properties of translesion synthesis (TLS) polymerase bypass of 8-oxoG, oligonucleotides with an 8-oxoG in different sequence contexts were used. We conclude that the 5'-nearest base next to 8-oxoG has significant effects in the G → T mutation by hpolη. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| Relation: | http://nass.oxfordjournals.org/cgi/content/short/51/1/49; http://dx.doi.org/10.1093/nass/nrm025 |
| DOI: | 10.1093/nass/nrm025 |
| الاتاحة: | http://nass.oxfordjournals.org/cgi/content/short/51/1/49 https://doi.org/10.1093/nass/nrm025 |
| Rights: | Copyright (C) 2007, Oxford University Press |
| رقم الانضمام: | edsbas.CC17C473 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/nass/nrm025 |
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